Curcumin loaded nanocarriers obtained by self-assembly of a linear D,L-octapeptide-poly(ethylene glycol) conjugate

Federica Novelli, Serena De Santis, Marco Diociaiuti, Cesare Giordano, Stefano Morosetti, Pasqualina Punzi, Fabio Sciubba, Valerio Viali, Giancarlo Masci, Anita Scipioni

Research output: Contribution to journalArticle

Abstract

The preparation and characterization of a novel linear D,L-octapeptide-poly(ethylene glycol) conjugate, formulated as biocompatible nanocarrier of hydrophobic drugs, was reported. The PEGylated D,L-octapeptide was designed to self-assemble in core-shell nanoparticles with rod-like morphology obtained by exploiting the self-assembling properties of linear peptides with regularly alternating enantiomeric sequences in tubular structures. The conformational properties of the conjugate and its self-assembling capability were assessed through dynamic light scattering, energy filtered-transmission electron microscopy, scanning electron microscopy, circular dichroism, fluorescence, and proton nuclear magnetic resonance spectroscopy. Furthermore, the upload in peptide-polymer nanoparticles of curcumin, adopted as model of hydrophobic drugs, was performed. In fact, despite accumulating evidence suggests that curcumin has different therapeutic activities, its use in medicine is limited to the very low water solubility, low bioavailability and chemical instability. This work addresses such drawbacks showing that nanoparticles obtained by For-(D-Phe-L-Cys(Acm))4-NH-(CH2-CH2-O)45-CH3 self-assembly are effective carriers for curcumin with high drug loading and sustained drug release.

Original languageEnglish
Pages (from-to)28-38
Number of pages11
JournalEuropean Polymer Journal
Volume98
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Curcumin drug loading
  • Curcumin drug release
  • Linear D,L octapeptide
  • Peptide-poly(ethylene glycol) conjugate
  • Rod-like nanoparticles
  • Self-assembly

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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  • Cite this

    Novelli, F., De Santis, S., Diociaiuti, M., Giordano, C., Morosetti, S., Punzi, P., Sciubba, F., Viali, V., Masci, G., & Scipioni, A. (2018). Curcumin loaded nanocarriers obtained by self-assembly of a linear D,L-octapeptide-poly(ethylene glycol) conjugate. European Polymer Journal, 98, 28-38. https://doi.org/10.1016/j.eurpolymj.2017.11.010