Cure of Helicobacter pylori-positive active duodenal ulcer patients: A double-blind, multicentre, 12-month study comparing a two-week dual vs a one-week triple therapy

F. Di Mario, A. Caroli, V. Marcon, G. Ronzani, G. Battaglia, F. Costan-Biedo, R. Marin, A. Saggioro, N. Dal Bò, R. De Bastiani, F. Monica, G. Tafner, G. Leandro, B. Germanà, P. Olivieri, E. Benedetti, S. Andrea Grassi, N. Orzes, E. Bottona, D. MadiaA. Pilotto

Research output: Contribution to journalArticle

Abstract

Aims. To compare a two-week dual therapy to a one-week triple therapy for the healing of duodenal ulcer and the eradication of the Helicobacter pylori infection. Patients and Methods. A total of 165 patients with active duodenal ulcer were enrolled in the study. At entry, endoscopy, clinical examination and laboratory tests were performed. Histology and the rapid urease test were used to diagnose Helicobacter pylori infection. Patients received either lansoprazole 30 mg plus amoxycillin 1 g bid for two weeks (two-week, dual therapy) or lansoprazole 30 mg plus amoxycillin 1 g plus tinidazole 500 mg bid for one week plus lansoprazole qd for an additional week (one-week, triple therapy). Two and twelve months after cessation of therapy, endoscopy and clinical assessments were repeated. Results. Duodenal ulcer healing and Helicobacter pylori eradication were both significantly greater (p

Original languageEnglish
Pages (from-to)108-115
Number of pages8
JournalDigestive and Liver Disease
Volume32
Issue number2
Publication statusPublished - Mar 2000

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Cure of Helicobacter pylori-positive active duodenal ulcer patients: A double-blind, multicentre, 12-month study comparing a two-week dual vs a one-week triple therapy'. Together they form a unique fingerprint.

  • Cite this

    Di Mario, F., Caroli, A., Marcon, V., Ronzani, G., Battaglia, G., Costan-Biedo, F., Marin, R., Saggioro, A., Dal Bò, N., De Bastiani, R., Monica, F., Tafner, G., Leandro, G., Germanà, B., Olivieri, P., Benedetti, E., Andrea Grassi, S., Orzes, N., Bottona, E., ... Pilotto, A. (2000). Cure of Helicobacter pylori-positive active duodenal ulcer patients: A double-blind, multicentre, 12-month study comparing a two-week dual vs a one-week triple therapy. Digestive and Liver Disease, 32(2), 108-115.