Current and Future Status of Blood Flow Tracers

Alberto Cuocolo, Corrado Cittanti, Wanda Acampa, Michele Larobina, Mario Petretta

Research output: Contribution to journalArticlepeer-review


Myocardial perfusion imaging is important for the management of patients with suspected or known coronary artery disease. Nuclear cardiology is the most widely used noninvasive approach for the assessment of myocardial perfusion. The available single-photon emission CT (SPECT) flow agents are characterized by a rapid myocardial extraction and by a cardiac uptake proportional to blood flow. In addition, different positron emission tomography (PET) tracers may be used for the absolute quantitative measurement of myocardial blood flow and coronary flow reserve. However, the available SPECT and PET tracers for myocardial perfusion imaging have some limitations that must be considered to maximize their clinical applications and there is still a well-recognized need for the development of new perfusion tracers with more ideal properties. This review illustrates the current status and the future perspectives of blood flow tracers for SPECT and PET myocardial perfusion imaging.

Original languageEnglish
Pages (from-to)227-236
Number of pages10
JournalCurrent Cardiovascular Imaging Reports
Issue number3
Publication statusPublished - 2011


  • coronary flow reserve
  • Myocardial blood flow
  • PET
  • radiotracers

ASJC Scopus subject areas

  • Cell Biology
  • Histology
  • Applied Microbiology and Biotechnology


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