Current challenges and future perspectives in the medical treatment of solid tumours

A. Sobrero, M. Di Benedetto

Research output: Contribution to journalArticlepeer-review


We are making progresses in the treatment of cancer. Vaccines are effective in preventing hepatocellular carcinoma, cervical and head and neck carcinomas. The use of adjuvant or neoadjuvant medical treatments in breast, colon, rectal, ovarian and gastric cancer produces additional cure rates of 10-30%. And chemotherapy, hormonal treatment, and biologic agents have improved the outcome of metastatic cancer in every solid tumour, including the most refractory. However, resistance continues to be the main reason for failures in the advanced setting, and this is more pronounced amongst certain tumours where the progresses have been much limited: melanoma, biliary tract cancer, oesophageal, non-small cell lung cancer, brain tumours, etc. There are four main challenges for the near future: a better classification of tumours; a simplification and acceleration of the drug development process; a more courageous drug design and drug approval process.

Original languageEnglish
Pages (from-to)91-93
Number of pages3
JournalEuropean Journal of Cancer, Supplement
Issue number14
Publication statusPublished - Oct 2008


  • Biologic agents
  • Trial design

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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