Current challenges in sudden cardiac death prevention

Domenico Corrado, Alessandro Zorzi, Emilio Vanoli, Edoardo Gronda

Research output: Contribution to journalReview articlepeer-review


Ischemic heart disease and non-ischemic dilated cardiomyopathy are the most common causes of arrhythmic sudden cardiac death (SCD). Implantable cardioverter defibrillator (ICD) therapy is the only strategy that proved to be effective in preventing SCD in high-risk individuals while the role of antiarrhythmic drugs is limited to symptoms relief. Current guidelines recommend selecting candidates to ICD implantation based on etiology, symptoms of heart failure (NYHA class), and severely depressed left ventricular ejection fraction, but these parameters are neither sensitive nor specific. The review addresses the mechanisms of SCD in patients with heart failure of either ischemic or non-ischemic etiology, risk stratification, and strategies for prevention of SCD in the clinical practice (including optimization of heart failure therapy, avoidance of triggering factors, antiarrhythmic drugs, ICD therapy, early resuscitation, and public access defibrillators).

Original languageEnglish
Pages (from-to)99-106
Number of pages8
JournalHeart Failure Reviews
Issue number1
Publication statusPublished - Jan 1 2020


  • Antiarrhythmic drugs
  • Heart failure
  • Implantable cardioverter defibrillator
  • Resuscitation
  • Ventricular arrhythmias

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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