TY - JOUR
T1 - Current clinical applications of extracorporeal photochemotherapy
AU - Capuano, Maria
AU - Sommese, Linda
AU - Pignalosa, Orlando
AU - Parente, Delia
AU - Fabbricini, Rossella
AU - Nicoletti, Giovanni Francesco
AU - De Pascale, Maria Rosaria
AU - Schiano, Concetta
AU - Napoli, Claudio
PY - 2015/4/1
Y1 - 2015/4/1
N2 - From the 1980s, extracorporeal photochemotherapy (ECP) has been shown to be effective in a variety of pathological conditions such as erythrodermic cutaneous T-cell lymphoma, autoimmune diseases, solid organ allograft rejection and graft versus host disease. To date, ECP represents a non-aggressive immune modulatory therapy with a low spectrum of toxicity. ECP reduces the alloreactivity promoting the immune tolerance to self. At the same time, it allows the maintenance of immune response integrity of both naive and memory T-cells. However, the molecular mechanisms of action by which ECP exerts its therapeutic activity are still under investigation. Here, we review molecular mechanisms and clinical applications involved in ECP. The outcome of ECP is difficult due to the lack of reliable predictor factors for the selection of patients and their adequate follow-up. Since the study of such predictors is important, we also describe some biological markers that enable us to investigate the clinical management of the patients considered for the use of ECP.
AB - From the 1980s, extracorporeal photochemotherapy (ECP) has been shown to be effective in a variety of pathological conditions such as erythrodermic cutaneous T-cell lymphoma, autoimmune diseases, solid organ allograft rejection and graft versus host disease. To date, ECP represents a non-aggressive immune modulatory therapy with a low spectrum of toxicity. ECP reduces the alloreactivity promoting the immune tolerance to self. At the same time, it allows the maintenance of immune response integrity of both naive and memory T-cells. However, the molecular mechanisms of action by which ECP exerts its therapeutic activity are still under investigation. Here, we review molecular mechanisms and clinical applications involved in ECP. The outcome of ECP is difficult due to the lack of reliable predictor factors for the selection of patients and their adequate follow-up. Since the study of such predictors is important, we also describe some biological markers that enable us to investigate the clinical management of the patients considered for the use of ECP.
KW - Extracorporeal photochemoterapy
KW - Graft versus host disease
KW - Molecular mechanisms
UR - http://www.scopus.com/inward/record.url?scp=84926470186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84926470186&partnerID=8YFLogxK
U2 - 10.1111/1744-9987.12245
DO - 10.1111/1744-9987.12245
M3 - Article
C2 - 25363837
AN - SCOPUS:84926470186
VL - 19
SP - 103
EP - 110
JO - Therapeutic Apheresis and Dialysis
JF - Therapeutic Apheresis and Dialysis
SN - 1744-9979
IS - 2
ER -