Current concepts about inhibition of platelet aggregation

Research output: Contribution to journalArticle

Abstract

One hundred twenty-seven years after Professor Giulio Bizzozero described the blood particle that has come to be known as the platelet, antiplatelet therapy has revolutionized the treatment of cardiovascular disease. Platelet function testing, introduced in 1962 with the advent of Born's aggregometer, heralded a renaissance in platelet research and provided a platelet function test to study platelet reactivity in vitro to help the diagnosis of bleeding disorders. More devices to test platelet function have emerged since, and these are now being applied mainly to assess antiplatelet drug efficacy in thrombotic disorders. Although this may be a logical use for platelet function tests, the data are replete with contradictions, and there is a lack of both consensus and standardization of the methodology. As a result, the clinical validity of platelet function results to monitor response to antiplatelet drugs has yet to be established.

Original languageEnglish
Pages (from-to)565-570
Number of pages6
JournalPlatelets
Volume19
Issue number8
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Platelet Aggregation
Platelet Function Tests
Blood Platelets
Platelet Aggregation Inhibitors
Reproducibility of Results
Cardiovascular Diseases
Hemorrhage
Equipment and Supplies
Research
Therapeutics

Keywords

  • Antiplatelet
  • Antiplatelet drugs
  • Aspirin resistance
  • Platelet function tests
  • Platelets

ASJC Scopus subject areas

  • Hematology

Cite this

Current concepts about inhibition of platelet aggregation. / De Gaetano, Giovanni; Crescente, Marilena; Cerletti, Chiara.

In: Platelets, Vol. 19, No. 8, 12.2008, p. 565-570.

Research output: Contribution to journalArticle

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