Current epidemiology and antimicrobial resistance data for bacterial bloodstream infections in patients with hematologic malignancies: An Italian multicentre prospective survey

E. M. Trecarichi, L. Pagano, A. Candoni, D. Pastore, C. Cattaneo, R. Fanci, A. Nosari, M. Caira, A. Spadea, A. Busca, N. Vianelli, M. Tumbarello

Research output: Contribution to journalArticle

Abstract

A prospective cohort study was conducted in nine hematology wards at tertiary care centres or at university hospitals located throughout Italy from January 2009 to December 2012. All of the cases of bacterial bloodstream infection (BBSI) occurring in adult patients with hematologic malignancies were included. A total of 668 bacterial isolates were recovered in 575 BBSI episodes. Overall, the susceptibility rates of Gram-negative bacteria were 59.1% to ceftazidime, 20.1% to ciprofloxacin, 79.1% to meropenem, 85.2% to amikacin, 69.2% to gentamicin and 69.8% to piperacillin/tazobactam. Resistance to third-generation cephalosporins was found in 98/265 (36.9%) of Enterobacteriaceae isolates. Among Klebsiella pneumoniae strains, 15/43 (34.9%) were resistant to carbapenems. Of 66 Pseudomonas aeruginosa isolates, 46 (69.7%) were multidrug resistant. Overall, the susceptibility rates of Gram-positive bacteria were 97.4% to vancomycin and 94.2% to teicoplanin. Among the monomicrobial cases of BBSI, the 21-day mortality rate was significantly higher for those caused by Gram-negative bacteria compared to those caused by Gram-positive bacteria (47/278, 16.9% vs. 12/212, 5.6%; p

Original languageEnglish
Pages (from-to)337-343
Number of pages7
JournalClinical Microbiology and Infection
Volume21
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

Keywords

  • Antimicrobial resistance
  • Bacterial bloodstream infections
  • Epidemiology
  • Hematologic cancer
  • Mortality
  • Multidrug resistance

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Current epidemiology and antimicrobial resistance data for bacterial bloodstream infections in patients with hematologic malignancies: An Italian multicentre prospective survey'. Together they form a unique fingerprint.

  • Cite this