Current interpretation of myocardial stunning

Andrea Igoren Guaricci, Gabriella Bulzis, Gianluca Pontone, Pietro Scicchitano, Rossella Carbonara, Mark Rabbat, Delia De Santis, Marco Matteo Ciccone

Research output: Contribution to journalReview articlepeer-review

Abstract

Myocardial stunning is a temporary post-ischemic cardiac mechanical dysfunction. As such, it is a heterogeneous entity and different conditions can promote its occurrence. Transient coronary occlusion, increased production of catecholamines and endothelin, and myocardial inflammation are all possible causes of myocardial stunning. Possible underlying mechanisms include an oxyradical hypothesis, calcium overload, decreased responsiveness of myofilaments to calcium, and excitation-contraction uncoupling due to sarcoplasmic reticulum dysfunction. The aim of this review is to summarize the clinical conditions that may be responsible for stunned myocardium.

Original languageEnglish
JournalTrends in Cardiovascular Medicine
DOIs
Publication statusE-pub ahead of print - Nov 27 2017

Keywords

  • Journal Article
  • Review

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