Current knowledge in ultrasound-based liver elastography of pediatric patients

Christoph F. Dietrich, Roxana Sirli, Giovanna Ferraioli, Alina Popescu, Ioan Sporea, Corina Pienar, Christian Kunze, Heike Taut, Simone Schrading, Simona Bota, Dagmar Schreiber-Dietrich, Dong Yi

Research output: Contribution to journalReview article

Abstract

Studies performed using transient elastography (TE), point shear wave elastography (pSWE) and two-dimensional shear wave elastography (2D-SWE) have shown that these techniques are all feasible and accurate in children for the evaluation of liver fibrosis due to several etiologies. However, for some specific pediatric pathologies, such as biliary atresia, the evidence is still limited. As shown in adults, inflammation is a confounding factor when assessing fibrosis severity and care should be taken when interpreting the results. Due to the scarce comparative data between serological tests and elastography techniques in children, a definite conclusion regarding which is the best cannot be drawn. Neither non-invasive elastographic techniques nor laboratory scores allow determination of the presence and the degree of inflammation, necrosis, iron or copper deposits.

Original languageEnglish
Article number944
JournalApplied Sciences (Switzerland)
Volume8
Issue number6
DOIs
Publication statusPublished - Jun 7 2018

Keywords

  • Liver fibrosis
  • Pediatric
  • Shear wave elastography (SWE)
  • Stiffness
  • Ultrasound elastography

ASJC Scopus subject areas

  • Materials Science(all)
  • Instrumentation
  • Engineering(all)
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes

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  • Cite this

    Dietrich, C. F., Sirli, R., Ferraioli, G., Popescu, A., Sporea, I., Pienar, C., Kunze, C., Taut, H., Schrading, S., Bota, S., Schreiber-Dietrich, D., & Yi, D. (2018). Current knowledge in ultrasound-based liver elastography of pediatric patients. Applied Sciences (Switzerland), 8(6), [944]. https://doi.org/10.3390/app8060944