Current management of patients hospitalized with complicated skin and soft tissue infections across Europe (2010-2011): Assessment of clinical practice patterns and real-life effectiveness of antibiotics from the REACH study

J. Garau, H. Ostermann, J. Medina, M. Ávila, K. Mcbride, F. Blasi

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Abstract

Complicated skin and soft tissue infections (cSSTI) are common and frequently require treatment in hospital. Comprehensive current data on management practices in patients hospitalized with cSSTI are limited. REACH was a retrospective, observational cohort study designed to provide data on current clinical management of moderate to severe cSSTI in European hospitals. Data were collected via an electronic case report form from 129 sites in ten European countries. The study population comprised patients ≥18 years, hospitalized between March 2010 and February 2011 with cSSTI who received intravenous antibiotic treatment. Presented here is an analysis of the disease characteristics, treatment patterns during hospitalization and clinical outcomes identified by the study. The total population included 1995 patients (mean age 60.6 years; 57.7% male). Initial antibiotic treatment modification was reported in 39.6% (n = 791) of patients; it was more common in patients with co-morbidities (42.6%), those requiring surgical intervention (43.4%), those with more severe infections such as bacteraemia (51.6%) or with fascia affected (49.0%), those admitted to the intensive care unit (56.2%) and those with lesions > 50 cm2 (44.3%). A switch to narrower-spectrum antibiotic treatment (streamlining) occurred in 5.6% of patients. Mean length of hospital stay was 18.5 days (±19.9; median 12.0) and the total mortality rate was 3.4%. The data collected in REACH give a comprehensive and current view of real-life clinical management of cSSTI in European hospitals and provide evidence of a high rate of initial antibiotic treatment modification.

Original languageEnglish
JournalClinical Microbiology and Infection
Volume19
Issue number9
DOIs
Publication statusPublished - Sep 2013

Fingerprint

Physicians' Practice Patterns
Soft Tissue Infections
Anti-Bacterial Agents
Skin
Length of Stay
Therapeutics
Practice Management
Fascia
Bacteremia
Population
Observational Studies
Intensive Care Units
Hospitalization
Cohort Studies
Outcome Assessment (Health Care)
Morbidity
Mortality
Infection

Keywords

  • Antibiotic
  • Complicated skin and soft tissue infections
  • Epidemiology
  • Europe
  • Hospitalized
  • Management
  • Moderate-to-severe
  • Observational
  • Outcomes
  • Treatment modification

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

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title = "Current management of patients hospitalized with complicated skin and soft tissue infections across Europe (2010-2011): Assessment of clinical practice patterns and real-life effectiveness of antibiotics from the REACH study",
abstract = "Complicated skin and soft tissue infections (cSSTI) are common and frequently require treatment in hospital. Comprehensive current data on management practices in patients hospitalized with cSSTI are limited. REACH was a retrospective, observational cohort study designed to provide data on current clinical management of moderate to severe cSSTI in European hospitals. Data were collected via an electronic case report form from 129 sites in ten European countries. The study population comprised patients ≥18 years, hospitalized between March 2010 and February 2011 with cSSTI who received intravenous antibiotic treatment. Presented here is an analysis of the disease characteristics, treatment patterns during hospitalization and clinical outcomes identified by the study. The total population included 1995 patients (mean age 60.6 years; 57.7{\%} male). Initial antibiotic treatment modification was reported in 39.6{\%} (n = 791) of patients; it was more common in patients with co-morbidities (42.6{\%}), those requiring surgical intervention (43.4{\%}), those with more severe infections such as bacteraemia (51.6{\%}) or with fascia affected (49.0{\%}), those admitted to the intensive care unit (56.2{\%}) and those with lesions > 50 cm2 (44.3{\%}). A switch to narrower-spectrum antibiotic treatment (streamlining) occurred in 5.6{\%} of patients. Mean length of hospital stay was 18.5 days (±19.9; median 12.0) and the total mortality rate was 3.4{\%}. The data collected in REACH give a comprehensive and current view of real-life clinical management of cSSTI in European hospitals and provide evidence of a high rate of initial antibiotic treatment modification.",
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T2 - Assessment of clinical practice patterns and real-life effectiveness of antibiotics from the REACH study

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AU - Ostermann, H.

AU - Medina, J.

AU - Ávila, M.

AU - Mcbride, K.

AU - Blasi, F.

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N2 - Complicated skin and soft tissue infections (cSSTI) are common and frequently require treatment in hospital. Comprehensive current data on management practices in patients hospitalized with cSSTI are limited. REACH was a retrospective, observational cohort study designed to provide data on current clinical management of moderate to severe cSSTI in European hospitals. Data were collected via an electronic case report form from 129 sites in ten European countries. The study population comprised patients ≥18 years, hospitalized between March 2010 and February 2011 with cSSTI who received intravenous antibiotic treatment. Presented here is an analysis of the disease characteristics, treatment patterns during hospitalization and clinical outcomes identified by the study. The total population included 1995 patients (mean age 60.6 years; 57.7% male). Initial antibiotic treatment modification was reported in 39.6% (n = 791) of patients; it was more common in patients with co-morbidities (42.6%), those requiring surgical intervention (43.4%), those with more severe infections such as bacteraemia (51.6%) or with fascia affected (49.0%), those admitted to the intensive care unit (56.2%) and those with lesions > 50 cm2 (44.3%). A switch to narrower-spectrum antibiotic treatment (streamlining) occurred in 5.6% of patients. Mean length of hospital stay was 18.5 days (±19.9; median 12.0) and the total mortality rate was 3.4%. The data collected in REACH give a comprehensive and current view of real-life clinical management of cSSTI in European hospitals and provide evidence of a high rate of initial antibiotic treatment modification.

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