Current misconceptions in diagnosis and management of iron deficiency

Manuel Muñoz, Susana Gómez-Ramírez, Martin Besser, José Pavía, Fernando Gomollón, Giancarlo M Liumbruno, Sunil Bhandari, Mercé Cladellas, Aryeh Shander, Michael Auerbach

Research output: Contribution to journalReview article

Abstract

The prevention and treatment of iron deficiency is a major public health goal. Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product which meets the needs of the patient. However, there are a number of non-evidence-based misconceptions regarding the diagnosis and management of iron deficiency, with or without anaemia, as well as inconsistency of terminology and lack of clear guidance on clinical pathways. In particular, the pathogenesis of iron deficiency is still frequently not addressed and iron not replaced, with indiscriminate red cell transfusion used as a default therapy. In our experience, this imprudent practice continues to be endorsed by non-evidence-based misconceptions. The intent of the authors is to provide a consensus that effectively challenges these misconceptions, and to highlight evidence-based alternatives for appropriate management (referred to as key points). We believe that this approach to the management of iron deficiency may be beneficial for both patients and healthcare systems. We stress that this paper solely presents the Authors' independent opinions. No pharmaceutical company funded or influenced the conception, development or writing of the manuscript.

Original languageEnglish
Pages (from-to)422-437
Number of pages16
JournalBlood Transfusion
Volume15
Issue number5
DOIs
Publication statusPublished - Sep 2017

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    Muñoz, M., Gómez-Ramírez, S., Besser, M., Pavía, J., Gomollón, F., Liumbruno, G. M., Bhandari, S., Cladellas, M., Shander, A., & Auerbach, M. (2017). Current misconceptions in diagnosis and management of iron deficiency. Blood Transfusion, 15(5), 422-437. https://doi.org/10.2450/2017.0113-17