Current outcome of HLA identical sibling versus unrelated donor transplants in severe aplastic anemia: An EBMT analysis

Andrea Bacigalupo; Gerard Socie; Rose Marie Hamladji; Mahmoud Aljurf; Alexei Maschan; Slawomira Kyrcz-Krzemien; Alicja Cybicka; Henrik Sengelov; Ali Unal; Dietrich Beelen; Anna Locasciulli; Carlo Dufour; Jakob R. Passweg; Rosi Oneto; Alessio Signori; Judith C W Marsh

doi:10.3324/haematol.2014.115345

Current outcome of HLA identical sibling versus unrelated donor transplants in severe aplastic anemia: An EBMT analysis

Andrea Bacigalupo, Gerard Socie, Rose Marie Hamladji, Mahmoud Aljurf, Alexei Maschan, Slawomira Kyrcz-Krzemien, Alicja Cybicka, Henrik Sengelov, Ali Unal, Dietrich Beelen, Anna Locasciulli, Carlo Dufour, Jakob R. Passweg, Rosi Oneto, Alessio Signori, Judith C W Marsh

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

We have analyzed 1448 patients with acquired aplastic anemia grafted between 2005 and 2009, and compared outcome of identical sibling (n=940) versus unrelated donor (n=508) transplants. When compared to the latter, sibling transplants were less likely to be performed beyond 180 days from diagnosis (39% vs. 85%), to have a cytomegalovirus negative donor/recipient status (15% vs. 23%), to receive antithymocyte globulin in the conditioning (52% vs. 61%), and more frequently received marrow as a stem cell source (60% vs. 52%). Unrelated donor grafts had significantly more acute grade II-IV (25% vs. 13%) and significantly more chronic graft-versus-host disease (26% vs. 14%). In multivariate analysis, the risk of death of unrelated donor grafts was higher, but not significantly higher, compared to a sibling donor (P=0.16). The strongest negative predictor of survival was the use of peripheral blood as a stem cell source (P

Original language	English
Pages (from-to)	696-702
Number of pages	7
Journal	Haematologica
Volume	100
Issue number	5
DOIs	https://doi.org/10.3324/haematol.2014.115345
Publication status	Published - 2015

ASJC Scopus subject areas

Hematology

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Bacigalupo, A., Socie, G., Hamladji, R. M., Aljurf, M., Maschan, A., Kyrcz-Krzemien, S., Cybicka, A., Sengelov, H., Unal, A., Beelen, D., Locasciulli, A., Dufour, C., Passweg, J. R., Oneto, R., Signori, A., & Marsh, J. C. W. (2015). Current outcome of HLA identical sibling versus unrelated donor transplants in severe aplastic anemia: An EBMT analysis. Haematologica, 100(5), 696-702. https://doi.org/10.3324/haematol.2014.115345

Current outcome of HLA identical sibling versus unrelated donor transplants in severe aplastic anemia : An EBMT analysis. / Bacigalupo, Andrea; Socie, Gerard; Hamladji, Rose Marie; Aljurf, Mahmoud; Maschan, Alexei; Kyrcz-Krzemien, Slawomira; Cybicka, Alicja; Sengelov, Henrik; Unal, Ali; Beelen, Dietrich; Locasciulli, Anna; Dufour, Carlo; Passweg, Jakob R.; Oneto, Rosi; Signori, Alessio; Marsh, Judith C W.

In: Haematologica, Vol. 100, No. 5, 2015, p. 696-702.

Research output: Contribution to journal › Article › peer-review

Bacigalupo, A, Socie, G, Hamladji, RM, Aljurf, M, Maschan, A, Kyrcz-Krzemien, S, Cybicka, A, Sengelov, H, Unal, A, Beelen, D, Locasciulli, A, Dufour, C, Passweg, JR, Oneto, R, Signori, A & Marsh, JCW 2015, 'Current outcome of HLA identical sibling versus unrelated donor transplants in severe aplastic anemia: An EBMT analysis', Haematologica, vol. 100, no. 5, pp. 696-702. https://doi.org/10.3324/haematol.2014.115345

Bacigalupo, Andrea ; Socie, Gerard ; Hamladji, Rose Marie ; Aljurf, Mahmoud ; Maschan, Alexei ; Kyrcz-Krzemien, Slawomira ; Cybicka, Alicja ; Sengelov, Henrik ; Unal, Ali ; Beelen, Dietrich ; Locasciulli, Anna ; Dufour, Carlo ; Passweg, Jakob R. ; Oneto, Rosi ; Signori, Alessio ; Marsh, Judith C W. / Current outcome of HLA identical sibling versus unrelated donor transplants in severe aplastic anemia : An EBMT analysis. In: Haematologica. 2015 ; Vol. 100, No. 5. pp. 696-702.

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abstract = "We have analyzed 1448 patients with acquired aplastic anemia grafted between 2005 and 2009, and compared outcome of identical sibling (n=940) versus unrelated donor (n=508) transplants. When compared to the latter, sibling transplants were less likely to be performed beyond 180 days from diagnosis (39% vs. 85%), to have a cytomegalovirus negative donor/recipient status (15% vs. 23%), to receive antithymocyte globulin in the conditioning (52% vs. 61%), and more frequently received marrow as a stem cell source (60% vs. 52%). Unrelated donor grafts had significantly more acute grade II-IV (25% vs. 13%) and significantly more chronic graft-versus-host disease (26% vs. 14%). In multivariate analysis, the risk of death of unrelated donor grafts was higher, but not significantly higher, compared to a sibling donor (P=0.16). The strongest negative predictor of survival was the use of peripheral blood as a stem cell source (P",

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AU - Sengelov, Henrik

AU - Unal, Ali

AU - Beelen, Dietrich

AU - Locasciulli, Anna

AU - Dufour, Carlo

AU - Passweg, Jakob R.

AU - Oneto, Rosi

AU - Signori, Alessio

AU - Marsh, Judith C W

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