TY - JOUR
T1 - Current outcome of HLA identical sibling versus unrelated donor transplants in severe aplastic anemia
T2 - An EBMT analysis
AU - Bacigalupo, Andrea
AU - Socie, Gerard
AU - Hamladji, Rose Marie
AU - Aljurf, Mahmoud
AU - Maschan, Alexei
AU - Kyrcz-Krzemien, Slawomira
AU - Cybicka, Alicja
AU - Sengelov, Henrik
AU - Unal, Ali
AU - Beelen, Dietrich
AU - Locasciulli, Anna
AU - Dufour, Carlo
AU - Passweg, Jakob R.
AU - Oneto, Rosi
AU - Signori, Alessio
AU - Marsh, Judith C W
PY - 2015
Y1 - 2015
N2 - We have analyzed 1448 patients with acquired aplastic anemia grafted between 2005 and 2009, and compared outcome of identical sibling (n=940) versus unrelated donor (n=508) transplants. When compared to the latter, sibling transplants were less likely to be performed beyond 180 days from diagnosis (39% vs. 85%), to have a cytomegalovirus negative donor/recipient status (15% vs. 23%), to receive antithymocyte globulin in the conditioning (52% vs. 61%), and more frequently received marrow as a stem cell source (60% vs. 52%). Unrelated donor grafts had significantly more acute grade II-IV (25% vs. 13%) and significantly more chronic graft-versus-host disease (26% vs. 14%). In multivariate analysis, the risk of death of unrelated donor grafts was higher, but not significantly higher, compared to a sibling donor (P=0.16). The strongest negative predictor of survival was the use of peripheral blood as a stem cell source (P
AB - We have analyzed 1448 patients with acquired aplastic anemia grafted between 2005 and 2009, and compared outcome of identical sibling (n=940) versus unrelated donor (n=508) transplants. When compared to the latter, sibling transplants were less likely to be performed beyond 180 days from diagnosis (39% vs. 85%), to have a cytomegalovirus negative donor/recipient status (15% vs. 23%), to receive antithymocyte globulin in the conditioning (52% vs. 61%), and more frequently received marrow as a stem cell source (60% vs. 52%). Unrelated donor grafts had significantly more acute grade II-IV (25% vs. 13%) and significantly more chronic graft-versus-host disease (26% vs. 14%). In multivariate analysis, the risk of death of unrelated donor grafts was higher, but not significantly higher, compared to a sibling donor (P=0.16). The strongest negative predictor of survival was the use of peripheral blood as a stem cell source (P
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U2 - 10.3324/haematol.2014.115345
DO - 10.3324/haematol.2014.115345
M3 - Article
C2 - 25616576
AN - SCOPUS:84929151714
VL - 100
SP - 696
EP - 702
JO - Haematologica
JF - Haematologica
SN - 0390-6078
IS - 5
ER -