Current Pharmacological Management of Premature Ejaculation: A Systematic Review and Meta-analysis

Fabio Castiglione, Maarten Albersen, Petter Hedlund, Christian Gratzke, Andrea Salonia, Francois Giuliano

Research output: Contribution to journalArticlepeer-review


Context: Premature ejaculation (PE) is the most prevalent male sexual dysfunction. In the last few years, several pharmacologic approaches for oral or topical treatment of PE have been studied. Objective: To systematically review the literature on the outcome of pharmacologic interventions for PE on intravaginal ejaculation latency time (IELT) in comparison to placebo. Evidence acquisition: A systematic literature search of PubMed and Scopus using the term "premature ejaculation" was performed on 10 April 2015. Full-text articles on prospective randomized controlled trials (RCTs) investigating pharmacotherapy were included. The main outcome measure was IELT. Evidence synthesis: Out of 266 unique records, a total of 22 were reviewed. The majority of RCTs were of unclear methodological quality because of limited reporting of methods. Pooled evidence suggests that selective serotonin reuptake inhibitors (SSRIs), topical anesthetic creams (TAs), tramadol, and phosphodiesterase type 5 inhibitors (PDE5is) are more effective than placebo at increasing IELT (all p 2 > 70%). Only pooled analyses for dapoxetine 30mg and 60mg were characterized by homogeneous data (both I 2

Original languageEnglish
JournalEuropean Urology
Publication statusAccepted/In press - 2015


  • Ejaculation
  • Medical treatment
  • Pharmacology of ejaculation
  • Premature ejaculation

ASJC Scopus subject areas

  • Urology


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