Current projects in pre-analytics: Where to go?

Anna Sapino, Laura Annaratone, Caterina Marchiò

Research output: Contribution to journalArticlepeer-review

Abstract

The current clinical practice of tissue handling and sample preparation is multifaceted and lacks strict standardisation: this scenario leads to significant variability in the quality of clinical samples. Poor tissue preservation has a detrimental effect thus leading to morphological artefacts, hampering the reproducibility of immunocytochemical and molecular diagnostic results (protein expression, DNA gene mutations, RNA gene expression) and affecting the research outcomes with irreproducible gene expression and post-transcriptional data. Altogether, this limits the opportunity to share and pool national databases into European common databases. At the European level, standardization of pre-analytical steps is just at the beginning and issues regarding biospecimen collection and management are still debated. A joint (public–private) project entitled on standardization of tissue handling in pre-analytical procedures has been recently funded in Italy with the aim of proposing novel approaches to the neglected issue of pre-analytical procedures. In this chapter, we will show how investing in pre-analytics may impact both public health problems and practical innovation in solid tumour processing.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalRecent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
Volume199
DOIs
Publication statusPublished - 2015

Keywords

  • Fixation
  • Funding opportunities
  • Innovation
  • Ischaemia
  • Pre-analytic
  • Standardisation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Medicine(all)

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