Current Status of Islet Transplantation

Paolo Cravedi, Piero Ruggenenti, Andrea Remuzzi, Giuseppe Remuzzi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Islet transplantation has been proposed as a therapeutic option for patients with type 1 diabetes mellitus who have poor glycemic control with insulin therapy. The procedure is generally effective in reducing the frequency and severity of hypoglycemic episodes, but has a disappointingly low success rate in providing persistent insulin independence. Other issues that should be taken into account when considering islet transplantation include the side effects of the immunosuppressive therapy, alloimmunization, and the high costs. Even more importantly, whether islet transplantation prevents the progression of diabetic micro- and macrovascular complications more effectively than strict glycemic control with insulin is largely unknown yet. Until this evidence is provided, pancreatic islet transplantation should be considered as an experimental procedure, whose indications are limited to a highly selected group of type 1 diabetic patients with life-threatening hypoglycemic episodes.

Original languageEnglish
Title of host publicationRegenerative Medicine Applications in Organ Transplantation
PublisherElsevier Inc.
Pages583-598
Number of pages16
ISBN (Print)9780123985231
DOIs
Publication statusPublished - 2014

Keywords

  • Diabetic complications
  • Immunosuppression
  • Pancreas
  • Pancreatic islet transplantation
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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