Current status of kidney graft in 6 recipients after pregnancy

V. Mazzarella, C. Tozzo, F. Pisani, G. Tisone, G. Splendiani, C. U. Casciani

Research output: Contribution to journalArticlepeer-review

Abstract

To determine whether pregnancy has an adverse influence on survival or graft function, a retrospective study was conducted. A total of 321 renal transplant(rTx) patients were followed on a day hospital basis of Tor Vergata University of Rome between January 1981 and April 1996. Out of 90 female subjects, 74 of childbearing age (less than 45 years) underwent the study. Six women had 7 pregnancies which resulted in 5 live births and two first trimester abortions. In one case the pregnancy occurred at 4 months after rTx: spontaneous abortion and acute rejection with graft loss occurred, for the four successful pregnancies the preconception serum creatinine (sCr) was 1.34 mg/dl (range: 1.3-1.4) and remained stable at the end of follow-up. The woman with two successful pregnancies had a sCr increase after second pregnancy, but it has remained stable at 4 yrs after rTx. The pt receiving rTx at 1981 with successful pregnancy after two yrs, reached ESRD 7 yrs after delivery because chronic rejection. Our data are consistent with other studies demonstrating no contraindication to pregnancy in women with stable renal transplant and controlled blood pressure. However, careful interdisciplinary monitoring is needed to reduce maternal and fetal risks.

Original languageEnglish
Pages (from-to)213-215
Number of pages3
JournalInternational Journal of Immunopathology and Pharmacology
Volume10
Issue number3
Publication statusPublished - 1997

Keywords

  • Kidney transplant
  • Pregnancy
  • Renal failure

ASJC Scopus subject areas

  • Pharmacology

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