Current status of lung cancer screening

Research output: Contribution to journalArticlepeer-review

Abstract

Low-dose CT (LDCT) is effective in the early detection of lung cancer, providing higher resectability and long-term survival rates. The National Lung Screening Trial shows a statistically significant mortality reduction in LDCT compared with chest radiography. The efficacy and safety of annual LDCT screening in heavy smokers must be explored, and the magnitude of benefit compared with the cost of large-scale screening. Trials in Europe have different study designs and an observational arm. Strategies to reduce lung cancer mortality should combine early detection with primary prevention and innovative biologic approaches.

Original languageEnglish
Pages (from-to)129-140
Number of pages12
JournalThoracic Surgery Clinics
Volume23
Issue number2
DOIs
Publication statusPublished - May 2013

Keywords

  • Biomarkers
  • Early detection
  • Low-dose computed tomography
  • Lung cancer screening
  • Overdiagnosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Surgery

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