Current status of salvage robot-assisted laparoscopic prostatectomy for radiorecurrent prostate cancer

Bernardo Rocco, Gabriele Cozzi, Matteo Giulio Spinelli, Angelica Grasso, Daniela Varisco, Rafael F. Coelho, Vipul R. Patel

Research output: Contribution to journalArticle

Abstract

Radiation therapy (RT) is one of the treatment options for prostate cancer (PCa). Transperineal low-dose rate brachytherapy (BT) is another safe and effective technique for low-risk PCa. Recurrence after RT for localized PCa can be defined by a PSA value of 2 ng/mL above the nadir after RT, and biochemical recurrence (BCR) rate after RT is 40-60 %. In case of radiorecurrent PCa, treatment options include salvage radical prostatectomy (RP), cryo-therapy, high-intensity focused ultrasound (HIFU), and salvage BT. Only salvage RP has cancer control results for over 10-year follow-up in a substantial portion of patients (30-40 %). However, salvage RP is technically demanding, and experienced surgeons are needed; in fact, RT-induced cystitis, fibrosis, and tissue plane obliteration can lead to significant complications, such as rectal injuries, anastomot-ic stricture, and urinary incontinence. This review describes indications, oncologic and functional outcomes, surgical techniques, and complications of salvage robot-assisted RP.

Original languageEnglish
Pages (from-to)195-201
Number of pages7
JournalCurrent Urology Reports
Volume13
Issue number3
DOIs
Publication statusPublished - Jun 2012

Keywords

  • Brachytherapy
  • Endourology
  • Prostate cancer
  • Radiation failure
  • Radiation therapy
  • Radiorecurrent prostate cancer
  • Recurrence
  • Salvage robot-assisted laparoscopic prostatectomy
  • sRALP
  • Surgery

ASJC Scopus subject areas

  • Urology

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