Current surgical options for articular cartilage repair

G. M. Peretti, A. Pozzi, R. Ballis, D. Deponti, F. Pellacci

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Citations (Scopus)

Abstract

The articular cartilage lesions represent one of the major unsolved problems in the orthopaedic surgery. This is because articular cartilage has a limited capacity of self-repair following trauma. The aim of this study is to review the different surgical options for articular cartilage repair. They can be divided into three groups: techniques without transplant of cells or tissues; techniques based on the transplantation of tissues; the tissue engineering techniques. The first group includes the joint debridement and the techniques based on the bone marrow-stimulation principle. The second group includes the transplantation of periosteum and the transplantation of autologous or allogeneic osteochondral plugs. The tissue engineering techniques could be further divided as follows: methods based on the transplantation of cells either in solution, or in the form of microspheres, or carried on a biocompatible scaffold; the transplant of cartilage fragments; the cell-free techniques, based on the use of an acellular scaffold, able to entrap the reparative cells recruited from the host tissue and to guide their differentiation toward a chondral phenotype. In this work we present various options for the treatment of chondral or osteochondral lesions. Today, however, due to the lack of comparative studies, it is not always possible to define the best treatment choice for the different cartilage pathologies.

Original languageEnglish
Title of host publicationActa Neurochirurgica, Supplementum
Pages213-219
Number of pages7
Edition108
DOIs
Publication statusPublished - 2011

Publication series

NameActa Neurochirurgica, Supplementum
Number108
ISSN (Print)00651419
ISSN (Electronic)00016268

Fingerprint

Articular Cartilage
Cartilage
Tissue Engineering
Transplants
Tissue Transplantation
Periosteum
Autologous Transplantation
Cell Transplantation
Homologous Transplantation
Debridement
Microspheres
Orthopedics
Joints
Transplantation
Bone Marrow
Pathology
Phenotype
Wounds and Injuries
Therapeutics

Keywords

  • Cartilage
  • Osteo-chondral defects
  • Scaffold
  • Tissue engineering

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Peretti, G. M., Pozzi, A., Ballis, R., Deponti, D., & Pellacci, F. (2011). Current surgical options for articular cartilage repair. In Acta Neurochirurgica, Supplementum (108 ed., pp. 213-219). (Acta Neurochirurgica, Supplementum; No. 108). https://doi.org/10.1007/978-3-211-99370-5_33

Current surgical options for articular cartilage repair. / Peretti, G. M.; Pozzi, A.; Ballis, R.; Deponti, D.; Pellacci, F.

Acta Neurochirurgica, Supplementum. 108. ed. 2011. p. 213-219 (Acta Neurochirurgica, Supplementum; No. 108).

Research output: Chapter in Book/Report/Conference proceedingChapter

Peretti, GM, Pozzi, A, Ballis, R, Deponti, D & Pellacci, F 2011, Current surgical options for articular cartilage repair. in Acta Neurochirurgica, Supplementum. 108 edn, Acta Neurochirurgica, Supplementum, no. 108, pp. 213-219. https://doi.org/10.1007/978-3-211-99370-5_33
Peretti GM, Pozzi A, Ballis R, Deponti D, Pellacci F. Current surgical options for articular cartilage repair. In Acta Neurochirurgica, Supplementum. 108 ed. 2011. p. 213-219. (Acta Neurochirurgica, Supplementum; 108). https://doi.org/10.1007/978-3-211-99370-5_33
Peretti, G. M. ; Pozzi, A. ; Ballis, R. ; Deponti, D. ; Pellacci, F. / Current surgical options for articular cartilage repair. Acta Neurochirurgica, Supplementum. 108. ed. 2011. pp. 213-219 (Acta Neurochirurgica, Supplementum; 108).
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