TY - JOUR
T1 - Current treatment options for metastatic hormone-sensitive prostate cancer
AU - Cattrini, Carlo
AU - Castro, Elena
AU - Lozano, Rebeca
AU - Zanardi, Elisa
AU - Rubagotti, Alessandra
AU - Boccardo, Francesco
AU - Olmos, David
PY - 2019/9/1
Y1 - 2019/9/1
N2 - The possible treatments options for metastatic hormone-sensitive prostate cancer (mHSPC) have dramatically increased during the last years. The old backbone, which androgen-deprivation therapy (ADT) is the exclusive approach for hormone-naïve patients, has been disrupted. Despite the fact that several high-quality, randomized, controlled phase 3 trials have been conducted in this setting, no direct comparison is currently available among the different strategies. Inadequate power, absence of preplanning and small sample size frequently affect the subgroup analyses according to disease volume or patient’s risk. The choice between ADT alone and ADT combined with docetaxel, abiraterone acetate, enzalutamide, apalutamide or radiotherapy to the primary tumor remains challenging. Factors that are related to the tumor, patient or drug side effects, currently guide these clinical decisions. This comprehensive review aims to indirectly compare the phase 3 trials in the mHSPC setting, in order to extrapolate data useful for treatment selection, providing also perspectives on future biomarkers.
AB - The possible treatments options for metastatic hormone-sensitive prostate cancer (mHSPC) have dramatically increased during the last years. The old backbone, which androgen-deprivation therapy (ADT) is the exclusive approach for hormone-naïve patients, has been disrupted. Despite the fact that several high-quality, randomized, controlled phase 3 trials have been conducted in this setting, no direct comparison is currently available among the different strategies. Inadequate power, absence of preplanning and small sample size frequently affect the subgroup analyses according to disease volume or patient’s risk. The choice between ADT alone and ADT combined with docetaxel, abiraterone acetate, enzalutamide, apalutamide or radiotherapy to the primary tumor remains challenging. Factors that are related to the tumor, patient or drug side effects, currently guide these clinical decisions. This comprehensive review aims to indirectly compare the phase 3 trials in the mHSPC setting, in order to extrapolate data useful for treatment selection, providing also perspectives on future biomarkers.
KW - Abiraterone acetate
KW - Apalutamide
KW - Docetaxel
KW - Enzalutamide
KW - Hormone-naïve prostate cancer
KW - Hormone-sensitive prostate cancer
KW - Radiotherapy
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U2 - 10.3390/cancers11091355
DO - 10.3390/cancers11091355
M3 - Review article
AN - SCOPUS:85073317021
VL - 11
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 9
M1 - 1355
ER -