Current use and potential role of procalcitonin in the diagnostic work up and follow up of febrile neutropenia in hematological patients

Benedetto Bruno, Alessandro Busca, Stefano Vallero, Stefania Raviolo, Nicola Mordini, Luca Nassi, Alessandro Cignetti, Ernesta Audisio, Moreno Festuccia, Alessandra Corsetti, Lorella Depaoli, Maura Faraci, Concetta Micalizzi, Silvia Corcione, Massimo Berger, Francesco Saglio, Paola Caropreso, Giulio Mengozzi, Vincenzo Squadrone, Francesco Giuseppe De RosaLuisa Giaccone

Research output: Contribution to journalReview articlepeer-review


INTRODUCTION: Febrile neutropenia (FN) represents a life-threatening complication in hematological malignancies. Its etiology is most often due to infections even though FN of other origins, such as tumor-related fever and non-infectious inflammation, should rapidly be ruled out. Initially, C-reactive protein and, more recently, procalcitonin (PCT) have been proposed as useful biomarkers for differential diagnosis. PCT was shown to be a good biomarker of bacterial infections and their clinical outcomes. Definition of standard cut-offs and design of PCT-guided treatment protocols remain however to be defined. Areas covered: In this review, highlights on the current clinical use of PCT and its potential role as a diagnostic tool have been discussed by a panel of physicians from different areas of expertise. We provide current clinical evidence that PCT has been shown to be a reliable biomarker to differentiate fever of bacterial origin from other causes. Moreover, the Authors convened to a round-table to discuss their 'real-life experience' and offer their recommendations by a Delphi survey. Expert commentary: PCT has an important clinical role in FN. Issues such as the validation of a specific decision algorithm that includes PCT to monitor antibiotic choice and treatment duration will be addressed in prospective studies.

Original languageEnglish
Pages (from-to)543-550
Number of pages8
JournalExpert Review of Hematology
Issue number6
Publication statusPublished - Jun 2017


  • Biomarkers
  • C-Reactive Protein
  • Calcitonin
  • Diagnosis, Differential
  • Febrile Neutropenia
  • Humans
  • Journal Article
  • Review


Dive into the research topics of 'Current use and potential role of procalcitonin in the diagnostic work up and follow up of febrile neutropenia in hematological patients'. Together they form a unique fingerprint.

Cite this