Currently used criteria for active surveillance in men with low-risk prostate cancer: An analysis of pathologic features

Nazareno Suardi, Umberto Capitanio, Felix K H Chun, Markus Graefen, Paul Perrotte, Thorsten Schlomm, Alexander Haese, Hartwig Huland, Andreas Erbersdobler, Francesco Montorsi, Pierre I. Karakiewicz

Research output: Contribution to journalArticle

Abstract

BACKGROUND. Active surveillance (AS) represents a treatment option for select patients with low-risk, organ-confined prostate cancer (PCa). In this report, the authors addressed the rates of misclassification associated with the use of 5 different clinical criteria for AS. Misclassification was defined as the presence of either nonorgan-confined disease or high-grade PCa. METHODS. Between 1992 and 2007, 4885 patients underwent radical prostatectomy (RP) at 1 of 2 European academic centers, and the patients were identified who fulfilled the criteria for AS according to 5 different investigational groups (Hardie et al, Roemeling et al, Choo et al, Klotz, and D'Amico and Coleman). Statistics targeted the rates of misclassification for each of the 5 definitions. RESULTS. Four thousand three hundred eight patients, 4047 patients, 3993 patients, 2455 patients, and 2345 patients fulfilled the AS criteria of Hardie et al, Roemeling et al, Choo et al, Klotz, and D'Amico and Coleman, respectively. Extracapsular extension was reported in 13.5% to 26% of patients, and seminal vesicle invasion was reported in 2.9% to 8.2% of patients. When PCa with Gleason scores from 8 to 10 at RP was considered high grade, the misclassification rates were 27%, 25%, 25%, 15%, and 14% for the 5 studies, respectively. Conversely, when PCa with Gleason scores from 7 to 10 was considered high grade, the misclassification rates increased to 56%, 55%, 45%, 42%, and 39%, respectively. CONCLUSIONS. The currently available AS criteria are limited by a high rate of misclassification. The use of more selective AS criteria may reduce the rate of misclassification but also may reduce significantly the percentage of patients who may be considered for AS.

Original languageEnglish
Pages (from-to)2068-2072
Number of pages5
JournalCancer
Volume113
Issue number8
DOIs
Publication statusPublished - Oct 15 2008

Keywords

  • Active surveillance
  • Extracapsular extension
  • Low risk
  • Prostate cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Suardi, N., Capitanio, U., Chun, F. K. H., Graefen, M., Perrotte, P., Schlomm, T., Haese, A., Huland, H., Erbersdobler, A., Montorsi, F., & Karakiewicz, P. I. (2008). Currently used criteria for active surveillance in men with low-risk prostate cancer: An analysis of pathologic features. Cancer, 113(8), 2068-2072. https://doi.org/10.1002/cncr.23827