Cushing’s disease and marked hyperprolactinemia in a patient with a pituitary macroadenoma: effectiveness of bromocriptine treatment

G. Verde, P. Loli, M. E. Berselli, M. Tagliaferri, D. Dallabonzana, G. Oppizzi, A. Liuzzi, P. G. Chiodini, G. Luccarelli, S. Lodrini

Research output: Contribution to journalArticle

Abstract

The case of a young boy bearing a pituitary PRL secreting adenoma (20–30,000 ng/ml) with the unusual association of clinical and endocrinological features of Cushing’s disease successfully treated with bromocriptine is described. Brain computed tomography evidenced a huge pituitary adenoma leading to visual field defects and raised intracranial pressure. Due to the very large size of the tumor, which rendered the complete neurosurgical removal unlikely, medical treatment with bromocriptine (10 mg/day) was started. Follow-up for more than six months demonstrated an impressive reduction of tumor size, the lowering of prolactin levels into the normal range, the normalization of visual field, and the regression of both clinical and biochemical signs of hypercortisolism.

Original languageEnglish
Pages (from-to)51-54
Number of pages4
JournalJournal of Endocrinological Investigation
Volume7
Issue number1
DOIs
Publication statusPublished - 1984

Fingerprint

Pituitary ACTH Hypersecretion
Hyperprolactinemia
Bromocriptine
Visual Fields
Prolactinoma
Cushing Syndrome
Intracranial Pressure
Pituitary Neoplasms
Prolactin
Neoplasms
Reference Values
Tomography
Brain
Therapeutics

Keywords

  • bromocriptine
  • Cushing’s disease
  • pituitary adenoma
  • tumoral hyperprolactinemia

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Cushing’s disease and marked hyperprolactinemia in a patient with a pituitary macroadenoma : effectiveness of bromocriptine treatment. / Verde, G.; Loli, P.; Berselli, M. E.; Tagliaferri, M.; Dallabonzana, D.; Oppizzi, G.; Liuzzi, A.; Chiodini, P. G.; Luccarelli, G.; Lodrini, S.

In: Journal of Endocrinological Investigation, Vol. 7, No. 1, 1984, p. 51-54.

Research output: Contribution to journalArticle

Verde, G, Loli, P, Berselli, ME, Tagliaferri, M, Dallabonzana, D, Oppizzi, G, Liuzzi, A, Chiodini, PG, Luccarelli, G & Lodrini, S 1984, 'Cushing’s disease and marked hyperprolactinemia in a patient with a pituitary macroadenoma: effectiveness of bromocriptine treatment', Journal of Endocrinological Investigation, vol. 7, no. 1, pp. 51-54. https://doi.org/10.1007/BF03348376
Verde, G. ; Loli, P. ; Berselli, M. E. ; Tagliaferri, M. ; Dallabonzana, D. ; Oppizzi, G. ; Liuzzi, A. ; Chiodini, P. G. ; Luccarelli, G. ; Lodrini, S. / Cushing’s disease and marked hyperprolactinemia in a patient with a pituitary macroadenoma : effectiveness of bromocriptine treatment. In: Journal of Endocrinological Investigation. 1984 ; Vol. 7, No. 1. pp. 51-54.
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