Cushing’s syndrome due to unilateral adrenal nodular hyperplasia with incomplete inhibition of the contralateral gland

Anna Catania, Eugenio Reschini, Alessandro Orsatli, Paata Motta, Lorena Airaghi, Luigi Cantalamessaa

Research output: Contribution to journalArticlepeer-review

Abstract

A 57-year-old woman was demonstrated to be affected by adrenocorticotropic hormone (ACTH)-independent Cushing’s syndrome. Computed-axial tomography of the abdomen demonstrated an expansion of the left adrenal. In apparent contrast with these findings, adrenal scintigraphy demonstrated radiocholesterol uptake also by the right gland. At surgery, the left adrenal was found to be hard and enlarged and was excised, while the right gland was found of normal appearance and left in place. Histologic examination of the excised gland demonstrated nodular hyperplasia. Early after surgery, plasma cortisol returned to normal values with a normal circadian rhythm and complete inhibition by low dose dexametha sone; the response of plasma cortisol to ACTH was normal. The patient represents a rare case of unilateral adrenal nodular hyperplasia. Radiocholesterol uptake by the contralateral gland and early recovery from adrenal atrophy after surgery are exceptional findings and suggest incomplete inhibition of endogenous ACTH.

Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalHormone Research in Paediatrics
Volume23
Issue number1
DOIs
Publication statusPublished - 1986

Keywords

  • Adrenal scintigraphy
  • Cushing’s syndrome
  • Nodular adrenal hyperplasia

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

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