Angiosarcoma cutaneo insorto in seguito a trattamento radioterapico di un carcinoma della mammella. Descrizione di un caso e revisione della letteratura

Translated title of the contribution: Cutaneous angiosarcoma following radiation therapy for breast cancer. A case report and review of the literature

Luca Di Tommaso, A. Fabbri

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Cutaneous angiosarcomas occurring as a complication of radiation therapy for breast cancer are rare. To the best of our knowledge 37 cases have been reported in english literature during the last two decades. We describe a case of angiosarcoma arising in the skin of a breast previously irradiated for breast carcinoma. The patient, a 74-years old woman, had been treated with conservative surgery and radiotherapy for a pT1N0 infiltrating ductal carcinoma of the left breast in 1993. Nine years later a skin lesion, which was interpreted as a recurrence, arose in the same site. A biopsy obteined from the lesion, and initially considered to be negative for cancer, showed istological features consistent with those of the atypical vascular lesion. Seven months later the same lesion trasfomed in a 5 × 3 reddish mass which at histological examination was diagnosed as an high grad post-irradiation angiosarcoma of the skin of the breast. Data on previously reported post iradiation angiosarcoma of the breast are reviewed; further consideration on differential diagnosis between those lesions and atypical vascular lesions are presented.

Original languageItalian
Pages (from-to)196-202
Number of pages7
JournalPathologica
Volume95
Issue number4
Publication statusPublished - Aug 2003

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Hemangiosarcoma
Radiotherapy
Breast Neoplasms
Skin
Blood Vessels
Carcinoma, Ductal, Breast
Breast
Differential Diagnosis
Biopsy
Recurrence
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

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abstract = "Cutaneous angiosarcomas occurring as a complication of radiation therapy for breast cancer are rare. To the best of our knowledge 37 cases have been reported in english literature during the last two decades. We describe a case of angiosarcoma arising in the skin of a breast previously irradiated for breast carcinoma. The patient, a 74-years old woman, had been treated with conservative surgery and radiotherapy for a pT1N0 infiltrating ductal carcinoma of the left breast in 1993. Nine years later a skin lesion, which was interpreted as a recurrence, arose in the same site. A biopsy obteined from the lesion, and initially considered to be negative for cancer, showed istological features consistent with those of the atypical vascular lesion. Seven months later the same lesion trasfomed in a 5 × 3 reddish mass which at histological examination was diagnosed as an high grad post-irradiation angiosarcoma of the skin of the breast. Data on previously reported post iradiation angiosarcoma of the breast are reviewed; further consideration on differential diagnosis between those lesions and atypical vascular lesions are presented.",
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AU - Fabbri, A.

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KW - Carcinoma

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