Cutaneous-group histiocytoses associated with myeloid malignancies: A systematic review of 102 cases

Arturo Bonometti, Jessica Gliozzo, Chiara Moltrasio, Filippo Bagnoli, Emilio Berti

Research output: Contribution to journalReview articlepeer-review


Background: Histiocytoses are haematological disorders of bone marrow origin that share many biological and clinical features with haematological neoplasms. The association between histiocytoses of the cutaneous-group and myeloid malignancies is a poorly investigated topic of high biological and clinical impact. Methods: We performed a systematic review of the scientific literature, compliant with PRISMA guidelines, to unravel the clinical and pathological features of this intriguing association. Findings: We gathered and analysed 102 patients. Most were children with generalised cutaneous eruptions and displayed risk organ involvement (i.e. bone marrow, spleen, liver). Interestingly, all these features are uncommonly encountered in C-group histiocytosis not associated with haematological neoplasms. Conclusions: Our review shows that generalised eruptions and risk organ involvement in cutaneous-group histiocytosis should raise a suspicion for a concomitant myeloid neoplasm both in children and in adults and warrant further investigations. A rapid recognition of this association is required to start a prompt and effective therapeutic management given the aggressive behaviour of the associated myeloid neoplasm in most instances.

Original languageEnglish
Pages (from-to)e162-e169
JournalAustralasian Journal of Dermatology
Issue number2
Publication statusPublished - May 2021


  • association
  • histiocytoses
  • leukaemia cutis
  • myeloid neoplasms
  • systematic review

ASJC Scopus subject areas

  • Dermatology


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