Cutaneous localization in multiple myeloma in the context of bortezomib-based treatment: how do myeloma cells escape from the bone marrow to the skin?

Valentina Marchica, Fabrizio Accardi, Paola Storti, Cristina Mancini, Eugenia Martella, Benedetta Dalla Palma, Marina Bolzoni, Katia Todoerti, Magda Marcatti, Chiara Schifano, Sabrina Bonomini, Gabriella Sammarelli, Antonino Neri, Maurilio Ponzoni, Franco Aversa, Nicola Giuliani

Research output: Contribution to journalArticle

Abstract

The skin is a possible site of extramedullary localization in multiple myeloma (MM) patients; however, the mechanisms involved in this process are poorly understood. We describe the case of a refractory MM patient who developed a cutaneous localization under bortezomib treatment and we further expanded observations in other eight MM patients. We focused on the expression of genes involved in plasma cell skin homing, including CCR10, which was highly expressed. Moreover, we observed a lack of CXCR4 surface expression and the down-regulation of ICAM1/CD54 throughout the progression of the disease, suggesting a possible mechanism driving the escape of MM cells from the bone marrow into the skin.

Original languageEnglish
Pages (from-to)104-108
Number of pages5
JournalInternational Journal of Hematology
Volume105
Issue number1
DOIs
Publication statusPublished - 2017

Keywords

  • Bone marrow
  • Extramedullary disease
  • Multiple myeloma
  • Skin homing

ASJC Scopus subject areas

  • Hematology

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    Marchica, V., Accardi, F., Storti, P., Mancini, C., Martella, E., Dalla Palma, B., Bolzoni, M., Todoerti, K., Marcatti, M., Schifano, C., Bonomini, S., Sammarelli, G., Neri, A., Ponzoni, M., Aversa, F., & Giuliani, N. (2017). Cutaneous localization in multiple myeloma in the context of bortezomib-based treatment: how do myeloma cells escape from the bone marrow to the skin? International Journal of Hematology, 105(1), 104-108. https://doi.org/10.1007/s12185-016-2104-1