Cutaneous localization of classic hodgkin lymphoma associated with mycosis fungoides: Report of a rare event and review of the literature

Magda Zanelli, Stefano Ricci, Francesca Sanguedolce, Andrea Palicelli, Enrico Farnetti, Alessandro Tafuni, Maurizio Zizzo, Riccardo Valli, Maria Isabel Alvarez De Celis, Alberto Cavazza, Caterina Longo, Stefano Ascani

Research output: Contribution to journalArticlepeer-review

Abstract

Mycosis fungoides and nodal classic Hodgkin lymphoma (cHL) have been reported to occur concurrently or sequentially in the same patient. A long-lasting mycosis fungoides more often precedes the onset of nodal cHL, although few cases of nodal cHL followed by mycosis fungoides have been observed. Skin involvement is a rare manifestation of cHL that may be observed in the setting of advanced disease. The decrease in skin involvement in cHL is mainly due to the improved therapeutic strategies. The concurrent presence of mycosis fungoides and cutaneous localization of classic Hodgkin lymphoma represents a very uncommon event, with only two cases reported so far. Herein, we describe the case of a 71-year-old man, with a history of recurrent nodal cHL, who developed MF and, subsequently, the cutaneous localization of cHL. The clinicopathological features of the two diseases are described focusing on the main differential diagnoses to be taken into consideration, and a review of the literature is performed.

Original languageEnglish
Article number1069
JournalLife
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 2021

Keywords

  • Classic Hodgkin lymphoma
  • Mycosis fungoides
  • Skin

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Space and Planetary Science
  • Palaeontology

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