Cutaneous malignant melanoma in females: The role of hormonal and reproductive factors

R. Zanetti, S. Franceschi, S. Rosso, E. Bidoli, S. Colonna

Research output: Contribution to journalArticle


The role of hormonal and reproductive factors as risks for cutaneous malignant melanoma (CMM) was explored by means of a population-based case-control study conducted in Turin, north-western Italy, on 186 female CMM cases and 205 controls. Past use of oral contraceptives (OC) did not seem to exert any effect on CMM risk odds ratio (OR) = 1.12, 95% confidence interval (CI): 0.56-2.24). No association was found even for the longest duration of use, for superficial spreading melanoma cases and for CMM of lower limbs only. While age at first birth did not affect CMM risk, women who had had three or more children seemed to be significantly protected as compared to nulliparous ones. The association was, however, substantially diminished by adjustment for education and other CMM risk correlates (OR for at least three children versus none = 0.62; 95% CI: 0.29-1.31).

Original languageEnglish
Pages (from-to)522-526
Number of pages5
JournalInternational Journal of Epidemiology
Issue number3
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Epidemiology
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Reproductive Medicine
  • Obstetrics and Gynaecology

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