Cutaneous melanoma in children and adolescents: The Italian rare tumors in pediatric age project experience

Andrea Ferrari, Gianni Bisogno, Giovanni Cecchetto, Mario Santinami, Andrea Maurichi, Aldo Bono, Marco Vajna De Pava, Paolo Pierani, Patrizia Bertolini, Carlo Riccardo Rossi, Gian Luca De Salvo

Research output: Contribution to journalArticlepeer-review


Objective To describe a series of cutaneous melanoma in children collected by the Italian Rare Tumors in Pediatric Age project. Study design From 2000 to 2012, 54 patients younger than 18 years of age were prospectively registered and treated at 12 Italian pediatric centers on the basis of the same diagnostic/therapeutic recommendations and with the same forms to record clinical data. Results Considering the estimated annual incidence in Italy, the registered cases accounted for 30% of those expected in children and 10% of adolescents. Clinically, 47% of the tumors were amelanotic and 81% were raised, 39% of cases had tumor thickness >2 mm, and 36% had lymph node involvement. For the whole series, 5-year event-free survival and overall survival rates were 75.2% and 84.6%, respectively. Patient survival correlated with tumor stage and ulceration. No relapses were recorded for T1-2 (thickness

Original languageEnglish
JournalJournal of Pediatrics
Issue number2
Publication statusPublished - Feb 2014


  • AJCC
  • American Joint Committee on Cancer
  • EFS
  • Event-free survival
  • OS
  • Overall survival
  • Sentinel lymph node biopsy
  • SLNB
  • TREP
  • Tumori Rari in Età Pediatrica (Rare Tumors in Pediatric Age)

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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