Cutaneous reactions to analgesic- antipyretics and nonsteroidal anti-inflammatory drugs: Analysis of reports to the spontaneous reporting system of the gruppo italiano studi epidemiologici in dermatologia

L. Naldi, C. Ferri, F. Locati, T. Camelli, T. Camelli, P. Lisi, A. Rebora, G. Tognoni, G. Zina, F. Grimaldi-Filioli, P. A. Villano, C. Moscariello, V. Guerrera, M. Florio, M. Pisani, G. Falgheri, A. Di Landro, A. Barcella, A. Reseghetti, G. ImbertiA. De Bitonto, F. Riva, A. Mariani, B. Pansera, P. Puiatti, M. Fassino, M. Tomidei, G. Doveil, M. Annunziata, A. M. Zina, M. Forte, R. Filotico, C. Foti, G. Angelini, G. A. Vena, F. Arcangeli, L. Brighi, S. Feletti, M. Leardini, M. Polverelli, G. Landi, A. Tosti, C. Misciali, A. D’Antuono, V. Zucchelli, C. Varotti, N. Baiato, S. De Rosa, F. Bordone, C. Patruno, P. Santoianni, A. R. Virgili, R. Strumia, V. Colombo, A. Negrini, A. Califano, P. Marinaro, M. I. Riva, E. Gennari, G. Galbiati, G. Pasolini, A. Manganoni, C. Leali, A. Carlino, D. Schena, A. Barba, S. Veraldi, G. Rizzitelli, R. Caputo, C. Veller-Fornasa, S. Poletto, A. Peserico, F. Cusano, A. G. Galiuccio, M. Capozzi, A. Burroni, A. Nigro, A. Farris, A. Fanti, P. E. Lombardi, S. Di Lorio, R. Becchilega, P. Perno, P. Lisi, A. Pestarino, A. Annonide, L. Massone, E. O. Galliera, M. Iannantuono, M. Lomuto, S. Giovanni Rotondo, E. Robert, F. Rongioletti, R. Betti, C. Crosti, S. Paolo, T. Di Prima, A. Sapuppo, A. Locatclli, F. Saggiorato, G. Fenizi, L. Altobella, S. Moretti, L. Barcella, G. M. Palleschi, F. Scardigli, F. Kokelj, A. Cimitan, P. Taddeucci, G. Cannata, V. Ingordo

Research output: Contribution to journalArticlepeer-review

Abstract

We analyzed the cutaneous reactions to systemic analgesic-antipyretics and nonsteroidal anti-inflammatory drugs reported to the spontaneous reporting system of the Gruppo Italiano Studi Epidemiologici in Dermatologia (GISED). The system has been active since 1988, with periodic intensive surveillance exercises, and 202 dermatologists have collaborated. Up to December 1991, 2,137 reactions had been collected, of which 713 were reactions to systemic analgesic-antipyretics and nonsteroidal anti-inflammatory drugs. A general profile of the reactions was identifiable. It included, in order of frequency, urticaria/angioedema, fixed eruptions, exanthemas, erythema multiforme and Stevens Johnson syndrome. Fixed eruptions and Stevens Johnson syndrome were reported with exceedingly high frequency in association with feprazone. Our system also revealed previously unreported reactions, including fixed eruption to nimesulide, fixed eruption to piroxicam and fixed eruption to flurbiprofen.

Original languageEnglish
Pages (from-to)164-169
Number of pages6
JournalDermatology
Volume186
Issue number3
DOIs
Publication statusPublished - 1993

Keywords

  • Analgesic-antipyretics and nonsteroidal anti-inflammatory drugs
  • Cutaneous adverse reactions
  • Spontaneous reporting system

ASJC Scopus subject areas

  • Dermatology

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