Cutaneous reactions to analgesic- antipyretics and nonsteroidal anti-inflammatory drugs

Analysis of reports to the spontaneous reporting system of the gruppo italiano studi epidemiologici in dermatologia

L. Naldi, C. Ferri, F. Locati, T. Camelli, T. Camelli, P. Lisi, A. Rebora, G. Tognoni, G. Zina, F. Grimaldi-Filioli, P. A. Villano, C. Moscariello, V. Guerrera, M. Florio, M. Pisani, G. Falgheri, A. Di Landro, A. Barcella, A. Reseghetti, G. Imberti & 91 others A. De Bitonto, F. Riva, A. Mariani, B. Pansera, P. Puiatti, M. Fassino, M. Tomidei, G. Doveil, M. Annunziata, A. M. Zina, M. Forte, R. Filotico, C. Foti, G. Angelini, G. A. Vena, F. Arcangeli, L. Brighi, S. Feletti, M. Leardini, M. Polverelli, G. Landi, A. Tosti, C. Misciali, A. D’Antuono, V. Zucchelli, C. Varotti, N. Baiato, S. De Rosa, F. Bordone, C. Patruno, P. Santoianni, A. R. Virgili, R. Strumia, V. Colombo, A. Negrini, A. Califano, P. Marinaro, M. I. Riva, E. Gennari, G. Galbiati, G. Pasolini, A. Manganoni, C. Leali, A. Carlino, D. Schena, A. Barba, S. Veraldi, G. Rizzitelli, R. Caputo, C. Veller-Fornasa, S. Poletto, A. Peserico, F. Cusano, A. G. Galiuccio, M. Capozzi, A. Burroni, A. Nigro, A. Farris, A. Fanti, P. E. Lombardi, S. Di Lorio, R. Becchilega, P. Perno, P. Lisi, A. Pestarino, A. Annonide, L. Massone, E. O. Galliera, M. Iannantuono, M. Lomuto, S. Giovanni Rotondo, E. Robert, F. Rongioletti, R. Betti, C. Crosti, S. Paolo, T. Di Prima, A. Sapuppo, A. Locatclli, F. Saggiorato, G. Fenizi, L. Altobella, S. Moretti, L. Barcella, G. M. Palleschi, F. Scardigli, F. Kokelj, A. Cimitan, P. Taddeucci, G. Cannata, V. Ingordo

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We analyzed the cutaneous reactions to systemic analgesic-antipyretics and nonsteroidal anti-inflammatory drugs reported to the spontaneous reporting system of the Gruppo Italiano Studi Epidemiologici in Dermatologia (GISED). The system has been active since 1988, with periodic intensive surveillance exercises, and 202 dermatologists have collaborated. Up to December 1991, 2,137 reactions had been collected, of which 713 were reactions to systemic analgesic-antipyretics and nonsteroidal anti-inflammatory drugs. A general profile of the reactions was identifiable. It included, in order of frequency, urticaria/angioedema, fixed eruptions, exanthemas, erythema multiforme and Stevens Johnson syndrome. Fixed eruptions and Stevens Johnson syndrome were reported with exceedingly high frequency in association with feprazone. Our system also revealed previously unreported reactions, including fixed eruption to nimesulide, fixed eruption to piroxicam and fixed eruption to flurbiprofen.

Original languageEnglish
Pages (from-to)164-169
Number of pages6
JournalDermatology
Volume186
Issue number3
DOIs
Publication statusPublished - 1993

Fingerprint

Stevens-Johnson Syndrome
Antipyretics
nimesulide
Analgesics
Feprazone
Anti-Inflammatory Agents
Flurbiprofen
Erythema Multiforme
Piroxicam
Angioedema
Skin
Urticaria
Exanthema
Pharmaceutical Preparations
Exercise
Dermatologists

Keywords

  • Analgesic-antipyretics and nonsteroidal anti-inflammatory drugs
  • Cutaneous adverse reactions
  • Spontaneous reporting system

ASJC Scopus subject areas

  • Dermatology

Cite this

Cutaneous reactions to analgesic- antipyretics and nonsteroidal anti-inflammatory drugs : Analysis of reports to the spontaneous reporting system of the gruppo italiano studi epidemiologici in dermatologia. / Naldi, L.; Ferri, C.; Locati, F.; Camelli, T.; Camelli, T.; Lisi, P.; Rebora, A.; Tognoni, G.; Zina, G.; Grimaldi-Filioli, F.; Villano, P. A.; Moscariello, C.; Guerrera, V.; Florio, M.; Pisani, M.; Falgheri, G.; Di Landro, A.; Barcella, A.; Reseghetti, A.; Imberti, G.; De Bitonto, A.; Riva, F.; Mariani, A.; Pansera, B.; Puiatti, P.; Fassino, M.; Tomidei, M.; Doveil, G.; Annunziata, M.; Zina, A. M.; Forte, M.; Filotico, R.; Foti, C.; Angelini, G.; Vena, G. A.; Arcangeli, F.; Brighi, L.; Feletti, S.; Leardini, M.; Polverelli, M.; Landi, G.; Tosti, A.; Misciali, C.; D’Antuono, A.; Zucchelli, V.; Varotti, C.; Baiato, N.; De Rosa, S.; Bordone, F.; Patruno, C.; Santoianni, P.; Virgili, A. R.; Strumia, R.; Colombo, V.; Negrini, A.; Califano, A.; Marinaro, P.; Riva, M. I.; Gennari, E.; Galbiati, G.; Pasolini, G.; Manganoni, A.; Leali, C.; Carlino, A.; Schena, D.; Barba, A.; Veraldi, S.; Rizzitelli, G.; Caputo, R.; Veller-Fornasa, C.; Poletto, S.; Peserico, A.; Cusano, F.; Galiuccio, A. G.; Capozzi, M.; Burroni, A.; Nigro, A.; Farris, A.; Fanti, A.; Lombardi, P. E.; Di Lorio, S.; Becchilega, R.; Perno, P.; Lisi, P.; Pestarino, A.; Annonide, A.; Massone, L.; Galliera, E. O.; Iannantuono, M.; Lomuto, M.; Giovanni Rotondo, S.; Robert, E.; Rongioletti, F.; Betti, R.; Crosti, C.; Paolo, S.; Di Prima, T.; Sapuppo, A.; Locatclli, A.; Saggiorato, F.; Fenizi, G.; Altobella, L.; Moretti, S.; Barcella, L.; Palleschi, G. M.; Scardigli, F.; Kokelj, F.; Cimitan, A.; Taddeucci, P.; Cannata, G.; Ingordo, V.

In: Dermatology, Vol. 186, No. 3, 1993, p. 164-169.

Research output: Contribution to journalArticle

Naldi, L, Ferri, C, Locati, F, Camelli, T, Camelli, T, Lisi, P, Rebora, A, Tognoni, G, Zina, G, Grimaldi-Filioli, F, Villano, PA, Moscariello, C, Guerrera, V, Florio, M, Pisani, M, Falgheri, G, Di Landro, A, Barcella, A, Reseghetti, A, Imberti, G, De Bitonto, A, Riva, F, Mariani, A, Pansera, B, Puiatti, P, Fassino, M, Tomidei, M, Doveil, G, Annunziata, M, Zina, AM, Forte, M, Filotico, R, Foti, C, Angelini, G, Vena, GA, Arcangeli, F, Brighi, L, Feletti, S, Leardini, M, Polverelli, M, Landi, G, Tosti, A, Misciali, C, D’Antuono, A, Zucchelli, V, Varotti, C, Baiato, N, De Rosa, S, Bordone, F, Patruno, C, Santoianni, P, Virgili, AR, Strumia, R, Colombo, V, Negrini, A, Califano, A, Marinaro, P, Riva, MI, Gennari, E, Galbiati, G, Pasolini, G, Manganoni, A, Leali, C, Carlino, A, Schena, D, Barba, A, Veraldi, S, Rizzitelli, G, Caputo, R, Veller-Fornasa, C, Poletto, S, Peserico, A, Cusano, F, Galiuccio, AG, Capozzi, M, Burroni, A, Nigro, A, Farris, A, Fanti, A, Lombardi, PE, Di Lorio, S, Becchilega, R, Perno, P, Lisi, P, Pestarino, A, Annonide, A, Massone, L, Galliera, EO, Iannantuono, M, Lomuto, M, Giovanni Rotondo, S, Robert, E, Rongioletti, F, Betti, R, Crosti, C, Paolo, S, Di Prima, T, Sapuppo, A, Locatclli, A, Saggiorato, F, Fenizi, G, Altobella, L, Moretti, S, Barcella, L, Palleschi, GM, Scardigli, F, Kokelj, F, Cimitan, A, Taddeucci, P, Cannata, G & Ingordo, V 1993, 'Cutaneous reactions to analgesic- antipyretics and nonsteroidal anti-inflammatory drugs: Analysis of reports to the spontaneous reporting system of the gruppo italiano studi epidemiologici in dermatologia', Dermatology, vol. 186, no. 3, pp. 164-169. https://doi.org/10.1159/000247338
Naldi, L. ; Ferri, C. ; Locati, F. ; Camelli, T. ; Camelli, T. ; Lisi, P. ; Rebora, A. ; Tognoni, G. ; Zina, G. ; Grimaldi-Filioli, F. ; Villano, P. A. ; Moscariello, C. ; Guerrera, V. ; Florio, M. ; Pisani, M. ; Falgheri, G. ; Di Landro, A. ; Barcella, A. ; Reseghetti, A. ; Imberti, G. ; De Bitonto, A. ; Riva, F. ; Mariani, A. ; Pansera, B. ; Puiatti, P. ; Fassino, M. ; Tomidei, M. ; Doveil, G. ; Annunziata, M. ; Zina, A. M. ; Forte, M. ; Filotico, R. ; Foti, C. ; Angelini, G. ; Vena, G. A. ; Arcangeli, F. ; Brighi, L. ; Feletti, S. ; Leardini, M. ; Polverelli, M. ; Landi, G. ; Tosti, A. ; Misciali, C. ; D’Antuono, A. ; Zucchelli, V. ; Varotti, C. ; Baiato, N. ; De Rosa, S. ; Bordone, F. ; Patruno, C. ; Santoianni, P. ; Virgili, A. R. ; Strumia, R. ; Colombo, V. ; Negrini, A. ; Califano, A. ; Marinaro, P. ; Riva, M. I. ; Gennari, E. ; Galbiati, G. ; Pasolini, G. ; Manganoni, A. ; Leali, C. ; Carlino, A. ; Schena, D. ; Barba, A. ; Veraldi, S. ; Rizzitelli, G. ; Caputo, R. ; Veller-Fornasa, C. ; Poletto, S. ; Peserico, A. ; Cusano, F. ; Galiuccio, A. G. ; Capozzi, M. ; Burroni, A. ; Nigro, A. ; Farris, A. ; Fanti, A. ; Lombardi, P. E. ; Di Lorio, S. ; Becchilega, R. ; Perno, P. ; Lisi, P. ; Pestarino, A. ; Annonide, A. ; Massone, L. ; Galliera, E. O. ; Iannantuono, M. ; Lomuto, M. ; Giovanni Rotondo, S. ; Robert, E. ; Rongioletti, F. ; Betti, R. ; Crosti, C. ; Paolo, S. ; Di Prima, T. ; Sapuppo, A. ; Locatclli, A. ; Saggiorato, F. ; Fenizi, G. ; Altobella, L. ; Moretti, S. ; Barcella, L. ; Palleschi, G. M. ; Scardigli, F. ; Kokelj, F. ; Cimitan, A. ; Taddeucci, P. ; Cannata, G. ; Ingordo, V. / Cutaneous reactions to analgesic- antipyretics and nonsteroidal anti-inflammatory drugs : Analysis of reports to the spontaneous reporting system of the gruppo italiano studi epidemiologici in dermatologia. In: Dermatology. 1993 ; Vol. 186, No. 3. pp. 164-169.
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abstract = "We analyzed the cutaneous reactions to systemic analgesic-antipyretics and nonsteroidal anti-inflammatory drugs reported to the spontaneous reporting system of the Gruppo Italiano Studi Epidemiologici in Dermatologia (GISED). The system has been active since 1988, with periodic intensive surveillance exercises, and 202 dermatologists have collaborated. Up to December 1991, 2,137 reactions had been collected, of which 713 were reactions to systemic analgesic-antipyretics and nonsteroidal anti-inflammatory drugs. A general profile of the reactions was identifiable. It included, in order of frequency, urticaria/angioedema, fixed eruptions, exanthemas, erythema multiforme and Stevens Johnson syndrome. Fixed eruptions and Stevens Johnson syndrome were reported with exceedingly high frequency in association with feprazone. Our system also revealed previously unreported reactions, including fixed eruption to nimesulide, fixed eruption to piroxicam and fixed eruption to flurbiprofen.",
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TY - JOUR

T1 - Cutaneous reactions to analgesic- antipyretics and nonsteroidal anti-inflammatory drugs

T2 - Analysis of reports to the spontaneous reporting system of the gruppo italiano studi epidemiologici in dermatologia

AU - Naldi, L.

AU - Ferri, C.

AU - Locati, F.

AU - Camelli, T.

AU - Camelli, T.

AU - Lisi, P.

AU - Rebora, A.

AU - Tognoni, G.

AU - Zina, G.

AU - Grimaldi-Filioli, F.

AU - Villano, P. A.

AU - Moscariello, C.

AU - Guerrera, V.

AU - Florio, M.

AU - Pisani, M.

AU - Falgheri, G.

AU - Di Landro, A.

AU - Barcella, A.

AU - Reseghetti, A.

AU - Imberti, G.

AU - De Bitonto, A.

AU - Riva, F.

AU - Mariani, A.

AU - Pansera, B.

AU - Puiatti, P.

AU - Fassino, M.

AU - Tomidei, M.

AU - Doveil, G.

AU - Annunziata, M.

AU - Zina, A. M.

AU - Forte, M.

AU - Filotico, R.

AU - Foti, C.

AU - Angelini, G.

AU - Vena, G. A.

AU - Arcangeli, F.

AU - Brighi, L.

AU - Feletti, S.

AU - Leardini, M.

AU - Polverelli, M.

AU - Landi, G.

AU - Tosti, A.

AU - Misciali, C.

AU - D’Antuono, A.

AU - Zucchelli, V.

AU - Varotti, C.

AU - Baiato, N.

AU - De Rosa, S.

AU - Bordone, F.

AU - Patruno, C.

AU - Santoianni, P.

AU - Virgili, A. R.

AU - Strumia, R.

AU - Colombo, V.

AU - Negrini, A.

AU - Califano, A.

AU - Marinaro, P.

AU - Riva, M. I.

AU - Gennari, E.

AU - Galbiati, G.

AU - Pasolini, G.

AU - Manganoni, A.

AU - Leali, C.

AU - Carlino, A.

AU - Schena, D.

AU - Barba, A.

AU - Veraldi, S.

AU - Rizzitelli, G.

AU - Caputo, R.

AU - Veller-Fornasa, C.

AU - Poletto, S.

AU - Peserico, A.

AU - Cusano, F.

AU - Galiuccio, A. G.

AU - Capozzi, M.

AU - Burroni, A.

AU - Nigro, A.

AU - Farris, A.

AU - Fanti, A.

AU - Lombardi, P. E.

AU - Di Lorio, S.

AU - Becchilega, R.

AU - Perno, P.

AU - Lisi, P.

AU - Pestarino, A.

AU - Annonide, A.

AU - Massone, L.

AU - Galliera, E. O.

AU - Iannantuono, M.

AU - Lomuto, M.

AU - Giovanni Rotondo, S.

AU - Robert, E.

AU - Rongioletti, F.

AU - Betti, R.

AU - Crosti, C.

AU - Paolo, S.

AU - Di Prima, T.

AU - Sapuppo, A.

AU - Locatclli, A.

AU - Saggiorato, F.

AU - Fenizi, G.

AU - Altobella, L.

AU - Moretti, S.

AU - Barcella, L.

AU - Palleschi, G. M.

AU - Scardigli, F.

AU - Kokelj, F.

AU - Cimitan, A.

AU - Taddeucci, P.

AU - Cannata, G.

AU - Ingordo, V.

PY - 1993

Y1 - 1993

N2 - We analyzed the cutaneous reactions to systemic analgesic-antipyretics and nonsteroidal anti-inflammatory drugs reported to the spontaneous reporting system of the Gruppo Italiano Studi Epidemiologici in Dermatologia (GISED). The system has been active since 1988, with periodic intensive surveillance exercises, and 202 dermatologists have collaborated. Up to December 1991, 2,137 reactions had been collected, of which 713 were reactions to systemic analgesic-antipyretics and nonsteroidal anti-inflammatory drugs. A general profile of the reactions was identifiable. It included, in order of frequency, urticaria/angioedema, fixed eruptions, exanthemas, erythema multiforme and Stevens Johnson syndrome. Fixed eruptions and Stevens Johnson syndrome were reported with exceedingly high frequency in association with feprazone. Our system also revealed previously unreported reactions, including fixed eruption to nimesulide, fixed eruption to piroxicam and fixed eruption to flurbiprofen.

AB - We analyzed the cutaneous reactions to systemic analgesic-antipyretics and nonsteroidal anti-inflammatory drugs reported to the spontaneous reporting system of the Gruppo Italiano Studi Epidemiologici in Dermatologia (GISED). The system has been active since 1988, with periodic intensive surveillance exercises, and 202 dermatologists have collaborated. Up to December 1991, 2,137 reactions had been collected, of which 713 were reactions to systemic analgesic-antipyretics and nonsteroidal anti-inflammatory drugs. A general profile of the reactions was identifiable. It included, in order of frequency, urticaria/angioedema, fixed eruptions, exanthemas, erythema multiforme and Stevens Johnson syndrome. Fixed eruptions and Stevens Johnson syndrome were reported with exceedingly high frequency in association with feprazone. Our system also revealed previously unreported reactions, including fixed eruption to nimesulide, fixed eruption to piroxicam and fixed eruption to flurbiprofen.

KW - Analgesic-antipyretics and nonsteroidal anti-inflammatory drugs

KW - Cutaneous adverse reactions

KW - Spontaneous reporting system

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U2 - 10.1159/000247338

DO - 10.1159/000247338

M3 - Article

VL - 186

SP - 164

EP - 169

JO - Dermatology

JF - Dermatology

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