Cutaneous reactive hyperaemia: racial differences induced by corticoid application

E. Berardesca, H. Maibach

Research output: Contribution to journalArticlepeer-review


The postocclusive hyperaemic reaction before and after a single 1 h application of a potent corticoid (clobetasol 0.05% in ointment) was recorded by means of laser Doppler velocimetry in order to elucidate different racial responses in skin vasoconstriction. Fourteen young male subjects entered the study (eight Caucasians, six Blacks). Reactive hyperaemia was recorded after 4 min of occlusion of the forearm blood flow. The following parameters of the hyperaemic reaction were investigated: area under the curve response, peak response, rise of blood flow slope to peak and decay of blood flow slope after peak. Different responses were recorded in the Black subjects after the vasoconstrictive stimulus compared to the Caucasians, namely: decreased area under the curve response (P

Original languageEnglish
Pages (from-to)787-794
Number of pages8
JournalBritish Journal of Dermatology
Issue number6
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Dermatology


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