TY - JOUR
T1 - Cutaneous silent period in hand muscles is lengthened by tramadol
T2 - Evidence for monoaminergic modulation?
AU - Pujia, Francesco
AU - Coppola, Gianluca
AU - Anastasio, Maria G.
AU - Brienza, Marianna
AU - Vestrini, Elisa
AU - Valente, Gabriele O.
AU - Parisi, Leoluca
AU - Serrao, Mariano
AU - Pierelli, Francesco
PY - 2012/10/18
Y1 - 2012/10/18
N2 - The purpose of this study was to shed light on the neurochemical modulatory mechanisms of the noxious spinal inhibitory cutaneous silent period (CSP). We study the effects of 100. mg of oral tramadol in 11 healthy volunteers. Tramadol has low affinity for opioid receptors and has the ability to inhibit serotonin and noradrenaline reuptake. We elicited CSPs in the first dorsal interosseus muscle and noxious withdrawal flexor reflexes (NWR) in the right biceps femoris muscle before, 30. min and each hour up to the 6th after tramadol. Subjective pain sensation was checked on an 11-point numerical scale. Tramadol increased duration of CSP, and reduced the NWR area under the curve maximally 2. h after tramadol and paralleled the reduction of subjective pain perception. We suggest that the monoaminergic action of tramadol reinforces the activity of spinal inhibitory interneurons on α-motoneurons for the hand muscles.
AB - The purpose of this study was to shed light on the neurochemical modulatory mechanisms of the noxious spinal inhibitory cutaneous silent period (CSP). We study the effects of 100. mg of oral tramadol in 11 healthy volunteers. Tramadol has low affinity for opioid receptors and has the ability to inhibit serotonin and noradrenaline reuptake. We elicited CSPs in the first dorsal interosseus muscle and noxious withdrawal flexor reflexes (NWR) in the right biceps femoris muscle before, 30. min and each hour up to the 6th after tramadol. Subjective pain sensation was checked on an 11-point numerical scale. Tramadol increased duration of CSP, and reduced the NWR area under the curve maximally 2. h after tramadol and paralleled the reduction of subjective pain perception. We suggest that the monoaminergic action of tramadol reinforces the activity of spinal inhibitory interneurons on α-motoneurons for the hand muscles.
KW - Brainstem descending system
KW - Cutaneous silent period
KW - Monoamines
KW - Noxious withdrawal flexor reflex
KW - Tramadol
UR - http://www.scopus.com/inward/record.url?scp=84866892475&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84866892475&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2012.08.064
DO - 10.1016/j.neulet.2012.08.064
M3 - Article
C2 - 22981885
AN - SCOPUS:84866892475
VL - 528
SP - 78
EP - 82
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -