A case of primary leiomyosarcoma of the skin localized on the back in a 63 years old female is described. The lesion was surgically excised and the histological examination revealed, in the superficial and middle dermis, a tumor consisting of cigar-shaped spindle cells with hyperchromatic nucei, arrangenged into irregular fascicles. Large atypical nuclei and mitotic figures were occasionally seen. Masson's trichrome, PAS and Gomori stainings documented the smooth muscle origin, whereas the immunohistochemical stainings revealed positivity for Vimentin, Actin and Desmin confirming the histological diagnosis of LMS. Primary LMS of the skin is commonly classified in cutaneous type, which is predominantly or exclusively intradermal and usually associated with local recurrence, and subcutaneous type that is recurrenting and metastatizanding. No recurrence has been observed after 5 year of follow up. The Autors discuss the clinical and histopathological aspect of LMS of the skin.
|Translated title of the contribution||Cutaneous superficial leiomyosarcoma: Clinical histochemical and immunohistochemical aspect of a case|
|Publication status||Published - 1998|
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