Cutaneous T-cell/histiocyte-rich B-cell lymphoma: A case report and review of the literature

Pamela Vezzoli, Roberta Fiorani, Valentina Girgenti, Daniele Fanoni, Simona Tavecchio, Ylenia Balice, Ruggero Mozzana, Carlo Crosti, Emilio Berti

Research output: Contribution to journalArticlepeer-review


Background: T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) primarily presenting on the skin is an extremely rare entity with only sporadic cases reported in the literature. Methods: We here report an extraordinary case of primary cutaneous THRLBCL with self-healing and 24 months of follow-up. Results: The lesion was a dermohypodermal/subcutaneous circumscribed ulcerated nodosity. Histological examination with immunohistochemical, molecular analysis and comparative genomic hybridization were performed. A complete staging was negative for secondary involvement. Conclusion: Our case is remarkable because it is the second well-documented primary cutaneous THRLBCL in which we observed a complete self-regression of skin lesions without recurrences or dissemination of the disease. According to the literature, we highlight that the tumoral microenvironment, in our case, could play a relevant role in stopping lymphoma growth. Furthermore, this case supports the observation that THRLBCL primarily presenting on the skin shows an overall good prognosis.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
Issue number3
Publication statusPublished - Jun 2011


  • Cutaneous presentation
  • T-cell/histiocyte-rich B-cell lymphoma
  • Tumoral microenvironment

ASJC Scopus subject areas

  • Dermatology


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