TY - JOUR
T1 - Cutaneous T-cell/histiocyte-rich B-cell lymphoma
T2 - A case report and review of the literature
AU - Vezzoli, Pamela
AU - Fiorani, Roberta
AU - Girgenti, Valentina
AU - Fanoni, Daniele
AU - Tavecchio, Simona
AU - Balice, Ylenia
AU - Mozzana, Ruggero
AU - Crosti, Carlo
AU - Berti, Emilio
PY - 2011/6
Y1 - 2011/6
N2 - Background: T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) primarily presenting on the skin is an extremely rare entity with only sporadic cases reported in the literature. Methods: We here report an extraordinary case of primary cutaneous THRLBCL with self-healing and 24 months of follow-up. Results: The lesion was a dermohypodermal/subcutaneous circumscribed ulcerated nodosity. Histological examination with immunohistochemical, molecular analysis and comparative genomic hybridization were performed. A complete staging was negative for secondary involvement. Conclusion: Our case is remarkable because it is the second well-documented primary cutaneous THRLBCL in which we observed a complete self-regression of skin lesions without recurrences or dissemination of the disease. According to the literature, we highlight that the tumoral microenvironment, in our case, could play a relevant role in stopping lymphoma growth. Furthermore, this case supports the observation that THRLBCL primarily presenting on the skin shows an overall good prognosis.
AB - Background: T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) primarily presenting on the skin is an extremely rare entity with only sporadic cases reported in the literature. Methods: We here report an extraordinary case of primary cutaneous THRLBCL with self-healing and 24 months of follow-up. Results: The lesion was a dermohypodermal/subcutaneous circumscribed ulcerated nodosity. Histological examination with immunohistochemical, molecular analysis and comparative genomic hybridization were performed. A complete staging was negative for secondary involvement. Conclusion: Our case is remarkable because it is the second well-documented primary cutaneous THRLBCL in which we observed a complete self-regression of skin lesions without recurrences or dissemination of the disease. According to the literature, we highlight that the tumoral microenvironment, in our case, could play a relevant role in stopping lymphoma growth. Furthermore, this case supports the observation that THRLBCL primarily presenting on the skin shows an overall good prognosis.
KW - Cutaneous presentation
KW - T-cell/histiocyte-rich B-cell lymphoma
KW - Tumoral microenvironment
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U2 - 10.1159/000327376
DO - 10.1159/000327376
M3 - Article
C2 - 21540569
AN - SCOPUS:79960001082
VL - 222
SP - 225
EP - 230
JO - Dermatology
JF - Dermatology
SN - 1018-8665
IS - 3
ER -