Ulcere cutanee vasculitiche in corso di terapia con sali di litio

Translated title of the contribution: Cutaneous vasculitic ulcers during treatment with litium salts

M. Gatti, M. Quaglini, E. Bignamini, M. Cespa

Research output: Contribution to journalArticlepeer-review


Lithium salts, in the form of carbonate and sulfate, are used in psychiatry in the therapy of maniacal psychosis and to prevent recurrent attacks in maniac-depressive psychosis. Litium salts are administered orally; they have a rapid absorption, the maximum seric concentration after 3 hours, and are renal excreted. Side-effects involve gastrointestinal, cardiovascular and central nervous system, kidney and skin (acne, folliculitis, psoriasis, dermatitis, vasculitis). A case of a 48-year-old woman under treatment with lithium carbonate for about 6 months is reported. The patient presented with erythematous-crusted lesions and malleolar edema. Skin biopsy for DIF and histological examination pointed out a leukocytoclastic vasculitis. At the beginning the patient was treated with glucocorticosteroids i.m. and anti-inflammatory drugs; the treatment was unsatisfactory and, after psychiatric consultation, lithium salts have been replaced with carbamazepine. The patient was periodically examined and a complete resolution of the clinical picture was observed after 45 days. In this case ulcerate lesions can be considered as a secondary effect of the treatment with lithium salts: in fact, they were not present at the beginning of the therapy with this drug, but appeared after same months.

Translated title of the contributionCutaneous vasculitic ulcers during treatment with litium salts
Original languageItalian
Pages (from-to)411-414
Number of pages4
JournalGiornale Italiano di Dermatologia e Venereologia
Issue number6
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Dermatology


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