Ulcere cutanee vasculitiche in corso di terapia con sali di litio

Translated title of the contribution: Cutaneous vasculitic ulcers during treatment with litium salts

M. Gatti, M. Quaglini, E. Bignamini, M. Cespa

Research output: Contribution to journalArticle

Abstract

Lithium salts, in the form of carbonate and sulfate, are used in psychiatry in the therapy of maniacal psychosis and to prevent recurrent attacks in maniac-depressive psychosis. Litium salts are administered orally; they have a rapid absorption, the maximum seric concentration after 3 hours, and are renal excreted. Side-effects involve gastrointestinal, cardiovascular and central nervous system, kidney and skin (acne, folliculitis, psoriasis, dermatitis, vasculitis). A case of a 48-year-old woman under treatment with lithium carbonate for about 6 months is reported. The patient presented with erythematous-crusted lesions and malleolar edema. Skin biopsy for DIF and histological examination pointed out a leukocytoclastic vasculitis. At the beginning the patient was treated with glucocorticosteroids i.m. and anti-inflammatory drugs; the treatment was unsatisfactory and, after psychiatric consultation, lithium salts have been replaced with carbamazepine. The patient was periodically examined and a complete resolution of the clinical picture was observed after 45 days. In this case ulcerate lesions can be considered as a secondary effect of the treatment with lithium salts: in fact, they were not present at the beginning of the therapy with this drug, but appeared after same months.

Original languageItalian
Pages (from-to)411-414
Number of pages4
JournalGiornale Italiano di Dermatologia e Venereologia
Volume137
Issue number6
Publication statusPublished - 2002

Fingerprint

Skin Ulcer
Salts
Lithium
Psychotic Disorders
Psychiatry
Folliculitis
Lithium Carbonate
Kidney
Skin
Carbonates
Carbamazepine
Acne Vulgaris
Dermatitis
Therapeutics
Vasculitis
Psoriasis
Sulfates
Edema
Anti-Inflammatory Agents
Referral and Consultation

ASJC Scopus subject areas

  • Dermatology

Cite this

Ulcere cutanee vasculitiche in corso di terapia con sali di litio. / Gatti, M.; Quaglini, M.; Bignamini, E.; Cespa, M.

In: Giornale Italiano di Dermatologia e Venereologia, Vol. 137, No. 6, 2002, p. 411-414.

Research output: Contribution to journalArticle

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