TY - JOUR
T1 - La profilassi della malattia reumatica in Italia
AU - Taddio, Andrea
AU - Pillon, Roberto
AU - Pastore, Serena
AU - Monasta, Lorenzo
AU - Tommasini, Alberto
AU - Battista, Caterina Di
AU - Mascheroni, Elisabetta
AU - Berton, Emanuela
AU - Maggio, Maria Cristina
AU - Simonini, Gabriele
AU - Breda, Luciana
AU - Cimaz, Rolando
AU - Marafon, Denise Pires
AU - Meli, Lidia
AU - Bracaglia, Claudia
AU - De Benedetti, Fabrizio
AU - Ventura, Alessandro
N1 - Publisher Copyright:
© 2020 Medico e Bambino. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/4
Y1 - 2020/4
N2 - Objective-The aim of the study is to evaluate the compliance rate to secondary prophylaxis and the presence of Rheumatic Heart Disease (RHD) in a cohort of Italian patients with Acute Rheumatic Fever (ARF). Methods-This is a multicentre retrospective study. Patients were divided into two groups according to the presence or absence at last follow-up of RHD. Clinical features, ARF recurrences and the rate of compliance to secondary prophylaxis were evaluated. Results-wo hundred and ninety patients were enrolled (137 females, 153 males). Carditis at onset was present in 244 patients (84.7%). At the end of follow-up, 173 patients showed RHD. Adherence to secondary prophylaxis was low in 26% of patients. The presence of RHD at follow-up was associated with the presence of carditis and its severity at onset (p = 0.001), but it was not related to secondary prophylaxis adherence (p = NS). No association between prophylaxis adherence and ARF recurrence was found p = NS) nor between ARF recurrence and RHD at the end of follow-up (p = NS). Conclusions-Poor adherence to secondary prophylaxis does not seem to be associated with increased risk of RHD in developed countries. Further studies are needed to confirm the reported data in a larger population.
AB - Objective-The aim of the study is to evaluate the compliance rate to secondary prophylaxis and the presence of Rheumatic Heart Disease (RHD) in a cohort of Italian patients with Acute Rheumatic Fever (ARF). Methods-This is a multicentre retrospective study. Patients were divided into two groups according to the presence or absence at last follow-up of RHD. Clinical features, ARF recurrences and the rate of compliance to secondary prophylaxis were evaluated. Results-wo hundred and ninety patients were enrolled (137 females, 153 males). Carditis at onset was present in 244 patients (84.7%). At the end of follow-up, 173 patients showed RHD. Adherence to secondary prophylaxis was low in 26% of patients. The presence of RHD at follow-up was associated with the presence of carditis and its severity at onset (p = 0.001), but it was not related to secondary prophylaxis adherence (p = NS). No association between prophylaxis adherence and ARF recurrence was found p = NS) nor between ARF recurrence and RHD at the end of follow-up (p = NS). Conclusions-Poor adherence to secondary prophylaxis does not seem to be associated with increased risk of RHD in developed countries. Further studies are needed to confirm the reported data in a larger population.
KW - Acute rheumatic fever
KW - Carditis
KW - Compliance
KW - Prophylaxis
KW - Rheumatic heart disease
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M3 - Articolo
AN - SCOPUS:85089479685
VL - 39
SP - 249
EP - 252
JO - Medico e Bambino
JF - Medico e Bambino
SN - 1591-3090
IS - 4
ER -