La profilassi della malattia reumatica in Italia

Translated title of the contribution: Cute rheumatic fever prophylaxis in high-income countries: Clinical observations from an italian multicentre retrospective study

Andrea Taddio, Roberto Pillon, Serena Pastore, Lorenzo Monasta, Alberto Tommasini, Caterina Di Battista, Elisabetta Mascheroni, Emanuela Berton, Maria Cristina Maggio, Gabriele Simonini, Luciana Breda, Rolando Cimaz, Denise Pires Marafon, Lidia Meli, Claudia Bracaglia, Fabrizio De Benedetti, Alessandro Ventura

Research output: Contribution to journalArticlepeer-review

Abstract

Objective-The aim of the study is to evaluate the compliance rate to secondary prophylaxis and the presence of Rheumatic Heart Disease (RHD) in a cohort of Italian patients with Acute Rheumatic Fever (ARF). Methods-This is a multicentre retrospective study. Patients were divided into two groups according to the presence or absence at last follow-up of RHD. Clinical features, ARF recurrences and the rate of compliance to secondary prophylaxis were evaluated. Results-wo hundred and ninety patients were enrolled (137 females, 153 males). Carditis at onset was present in 244 patients (84.7%). At the end of follow-up, 173 patients showed RHD. Adherence to secondary prophylaxis was low in 26% of patients. The presence of RHD at follow-up was associated with the presence of carditis and its severity at onset (p = 0.001), but it was not related to secondary prophylaxis adherence (p = NS). No association between prophylaxis adherence and ARF recurrence was found p = NS) nor between ARF recurrence and RHD at the end of follow-up (p = NS). Conclusions-Poor adherence to secondary prophylaxis does not seem to be associated with increased risk of RHD in developed countries. Further studies are needed to confirm the reported data in a larger population.

Translated title of the contributionCute rheumatic fever prophylaxis in high-income countries: Clinical observations from an italian multicentre retrospective study
Original languageItalian
Pages (from-to)249-252
Number of pages4
JournalMedico e Bambino
Volume39
Issue number4
Publication statusPublished - Apr 2020

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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