Cutting edge: Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function

Patrizia Rovere, Cristina Vallinoto, Attilio Bondanza, Maria Cristina Crosti, Maria Rescigno, Paola Ricciardi-Castagnoli, Claudio Rugarli, Angelo A. Manfredi

Research output: Contribution to journalArticle

Abstract

Physiologic cell death via apoptosis occurs without inflammation or autoimmunity. Here, we investigated the outcome of the interaction of apoptotic cells with dendritic cells (DCs), which are potent professional APCs. DCs internalized apoptotic cells and processed them for presentation to both MHC class I- and class II-restricted T cells with an efficiency that was dependent upon the number of apoptotic cells. The latter event was accompanied by the autocrine/paracrine secretion of IL-1β and TNF-α, with eventual DC maturation. High numbers of apoptotic cells, mimicking a failure of their in vivo clearance, are therefore sufficient to trigger pC maturation and the presentation of intracellular Ags from apoptotic cells, even in the absence of exogenous 'danger' signals.

Original languageEnglish
Pages (from-to)4467-4471
Number of pages5
JournalJournal of Immunology
Volume161
Issue number9
Publication statusPublished - Nov 1 1998

ASJC Scopus subject areas

  • Immunology

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    Rovere, P., Vallinoto, C., Bondanza, A., Crosti, M. C., Rescigno, M., Ricciardi-Castagnoli, P., Rugarli, C., & Manfredi, A. A. (1998). Cutting edge: Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function. Journal of Immunology, 161(9), 4467-4471.