TY - JOUR
T1 - Cutting edge
T2 - Bystander apoptosis triggers dendritic cell maturation and antigen-presenting function
AU - Rovere, Patrizia
AU - Vallinoto, Cristina
AU - Bondanza, Attilio
AU - Crosti, Maria Cristina
AU - Rescigno, Maria
AU - Ricciardi-Castagnoli, Paola
AU - Rugarli, Claudio
AU - Manfredi, Angelo A.
PY - 1998/11/1
Y1 - 1998/11/1
N2 - Physiologic cell death via apoptosis occurs without inflammation or autoimmunity. Here, we investigated the outcome of the interaction of apoptotic cells with dendritic cells (DCs), which are potent professional APCs. DCs internalized apoptotic cells and processed them for presentation to both MHC class I- and class II-restricted T cells with an efficiency that was dependent upon the number of apoptotic cells. The latter event was accompanied by the autocrine/paracrine secretion of IL-1β and TNF-α, with eventual DC maturation. High numbers of apoptotic cells, mimicking a failure of their in vivo clearance, are therefore sufficient to trigger pC maturation and the presentation of intracellular Ags from apoptotic cells, even in the absence of exogenous 'danger' signals.
AB - Physiologic cell death via apoptosis occurs without inflammation or autoimmunity. Here, we investigated the outcome of the interaction of apoptotic cells with dendritic cells (DCs), which are potent professional APCs. DCs internalized apoptotic cells and processed them for presentation to both MHC class I- and class II-restricted T cells with an efficiency that was dependent upon the number of apoptotic cells. The latter event was accompanied by the autocrine/paracrine secretion of IL-1β and TNF-α, with eventual DC maturation. High numbers of apoptotic cells, mimicking a failure of their in vivo clearance, are therefore sufficient to trigger pC maturation and the presentation of intracellular Ags from apoptotic cells, even in the absence of exogenous 'danger' signals.
UR - http://www.scopus.com/inward/record.url?scp=0032209520&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032209520&partnerID=8YFLogxK
M3 - Article
C2 - 9794367
AN - SCOPUS:0032209520
VL - 161
SP - 4467
EP - 4471
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 9
ER -