Cutting edge: Differential regulation of chemokine receptors during dendritic cell maturation: A model for their trafficking properties

Silvano Sozzani, Paola Allavena, Giovanna D'Amico, Walter Luini, Giancarlo Blanchi, Motoji Kataura, Toshio Imai, Osamu Yoshie, Raffaella Bonecchi, Alberto Mantovani

Research output: Contribution to journalArticle

Abstract

Upon exposure to immune or inflammatory stimuli, dendritic cells (DC) migrate from peripheral tissues to lymphoid organs, where they present Ag. CC chemokines induce chemotactic and transendothelial migration of immature DC, in vitro. Maturation of DC by CD40L, or by LPS, IL-1, and TNF, induces down- regulation of the two main CC chemokine receptors expressed by these cells, CCR1 and CCR5, and abrogates chemotaxis to their ligands. Inhibition was rapid (

Original languageEnglish
Pages (from-to)1083-1086
Number of pages4
JournalJournal of Immunology
Volume161
Issue number3
Publication statusPublished - Aug 1 1998

ASJC Scopus subject areas

  • Immunology

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