Cutting edge: Dissociation between autoimmune response and clinical disease after vaccination with dendritic cells

Attilio Bondanza, Valérie S. Zimmermann, Giacomo Dell'Antonio, Elena Dal Cin, Annalisa Capobianco, Maria Grazia Sabbadini, Angelo A. Manfredi, Patrizia Rovere-Querini

Research output: Contribution to journalArticlepeer-review

Abstract

Autoimmunity represents a caveat to the use of dendritic cells (DCs) as adjuvant for human vaccines. We derived DCs from normal BALB/c mice or from mice prone to autoimmunity (NZB × NZW) F1. We allowed DCs to phagocytose apoptotic thymocytes and vaccinated syngeneic animals. All mice developed anti-nuclear and antidsDNA Abs. Autoantibodies in normal mice were transient, without clinical or histological features of autoimmunity or tissue involvement. In contrast, autoimmunity was maintained in susceptible mice, which underwent renal failure and precociously died. The data suggest that DC vaccination consistently triggers autoimmune responses. However, clinical autoimmunity develops in susceptible subjects only.

Original languageEnglish
Pages (from-to)24-27
Number of pages4
JournalJournal of Immunology
Volume170
Issue number1
Publication statusPublished - Jan 1 2003

ASJC Scopus subject areas

  • Immunology

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