Cutting edge: Fasting-induced hypoleptinemia expands functional regulatory T cells in systemic lupus erythematosus

Yaoyang Liu, Yiyun Yu, Giuseppe Matarese, Antonio La Cava

Research output: Contribution to journalArticle

Abstract

Fasting is beneficial in the prevention and amelioration of the clinical manifestations of autoimmune diseases including systemic lupus erythematosus. The mechanisms responsible for these effects are not well understood. During fasting, there is a dramatic reduction of the levels of circulating leptin, an adipokine with proinflammatory effects. Leptin also inhibits CD4 +CD25 +Foxp3 + regulatory T cells, which are known to contribute significantly to the mechanisms of peripheral immune tolerance. In this study, we show that fasting-induced hypoleptinemia in (NZB X NZW)F 1 lupus-prone mice induced an expansion of functional regulatory T cells that was reversed by leptin replacement. The specificity of the findings was indicated by the lack of these effects in leptin-deficient ob/ob mice and leptin receptordeficient db/db mice. These observations help to explain the beneficial effects of fasting in autoimmunity and could be exploited for leptin-based immune intervention in systemic lupus erythematosus.

Original languageEnglish
Pages (from-to)2070-2073
Number of pages4
JournalJournal of Immunology
Volume188
Issue number5
DOIs
Publication statusPublished - Mar 1 2012

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Regulatory T-Lymphocytes
Leptin
Systemic Lupus Erythematosus
Fasting
Peripheral Tolerance
Immune Tolerance
Adipokines
Autoimmunity
Autoimmune Diseases

ASJC Scopus subject areas

  • Immunology

Cite this

Cutting edge : Fasting-induced hypoleptinemia expands functional regulatory T cells in systemic lupus erythematosus. / Liu, Yaoyang; Yu, Yiyun; Matarese, Giuseppe; La Cava, Antonio.

In: Journal of Immunology, Vol. 188, No. 5, 01.03.2012, p. 2070-2073.

Research output: Contribution to journalArticle

Liu, Yaoyang ; Yu, Yiyun ; Matarese, Giuseppe ; La Cava, Antonio. / Cutting edge : Fasting-induced hypoleptinemia expands functional regulatory T cells in systemic lupus erythematosus. In: Journal of Immunology. 2012 ; Vol. 188, No. 5. pp. 2070-2073.
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