Cutting edge: Inhibition of hepatitis B virus replication by activated NK T cells does not require inflammatory cell recruitment to the liver

K. Kakimi, T. E. Lane, F. V. Chisari, L. G. Guidotti

Research output: Contribution to journalArticlepeer-review

Abstract

We have previously reported that intrahepatic NK T cells activated by α-galactosylceramide inhibit hepatitis B virus replication noncytopathically in the liver of transgenic mice. This effect is mediated by antiviral cytokines directly produced by activated NK T cells and/or by other cytokine-producing inflammatory cells that are recruited into the liver. In this study, we demonstrated that IFN-γ produced by activated NK T cells induced parenchymal and nonparenchymal cells of the liver to produce high levels of CXC chemokine ligands 9 and 10, which mediated the intrahepatic recruitment of lymphomononuclear inflammatory cells. Recruitment of these cells was not necessary for the antiviral activity, indicating that direct activation of the intrahepatic resident NK T cell is sufficient to control viral replication in this model.

Original languageEnglish
Pages (from-to)6701-6705
Number of pages5
JournalJournal of Immunology
Volume167
Issue number12
Publication statusPublished - Dec 15 2001

ASJC Scopus subject areas

  • Immunology

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