Cutting edge

Inhibition of the retinoid X receptor (RXR) blocks T helper 2 differentiation and prevents allergic lung inflammation

Roland Grenningloh, Andrea Gho, Pietro Di Lucia, Michael Klaus, Werner Bollag, I. Cheng Ho, Francesco Sinigaglia, Paola Panina-Bordignon

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Among the many factors regulating Th cell differentiation, some nuclear hormone receptors are emerging as important players. The retinoid X receptor (RXR) functions as heterodimerization partner for a variety of nuclear hormone receptors. We show in this study that RXR is critical for Th2-mediated immunity. An RXR antagonist inhibited Th2 differentiation, resulting in reduced production of IL-4, IL-10, and IL-13, whereas IFN-γ production was enhanced. This effect was dependent on the presence of APCs. In addition, IL-5 production was blocked directly in Th cells. In vivo, inhibition of RXR prevented experimentally induced allergic lung inflammation. Th1-mediated inflammation was not affected. Its specific role in Th2-mediated inflammation makes RXR a promising target for the development of therapies against diseases such as allergic asthma and atopic dermatitis.

Original languageEnglish
Pages (from-to)5161-5166
Number of pages6
JournalJournal of Immunology
Volume176
Issue number9
Publication statusPublished - May 1 2006

Fingerprint

Retinoid X Receptors
Pneumonia
Cytoplasmic and Nuclear Receptors
Inflammation
Interleukin-13
Interleukin-5
Atopic Dermatitis
Interleukin-4
Interleukin-10
Cell Differentiation
Immunity
Asthma

ASJC Scopus subject areas

  • Immunology

Cite this

Grenningloh, R., Gho, A., Di Lucia, P., Klaus, M., Bollag, W., Ho, I. C., ... Panina-Bordignon, P. (2006). Cutting edge: Inhibition of the retinoid X receptor (RXR) blocks T helper 2 differentiation and prevents allergic lung inflammation. Journal of Immunology, 176(9), 5161-5166.

Cutting edge : Inhibition of the retinoid X receptor (RXR) blocks T helper 2 differentiation and prevents allergic lung inflammation. / Grenningloh, Roland; Gho, Andrea; Di Lucia, Pietro; Klaus, Michael; Bollag, Werner; Ho, I. Cheng; Sinigaglia, Francesco; Panina-Bordignon, Paola.

In: Journal of Immunology, Vol. 176, No. 9, 01.05.2006, p. 5161-5166.

Research output: Contribution to journalArticle

Grenningloh, R, Gho, A, Di Lucia, P, Klaus, M, Bollag, W, Ho, IC, Sinigaglia, F & Panina-Bordignon, P 2006, 'Cutting edge: Inhibition of the retinoid X receptor (RXR) blocks T helper 2 differentiation and prevents allergic lung inflammation', Journal of Immunology, vol. 176, no. 9, pp. 5161-5166.
Grenningloh, Roland ; Gho, Andrea ; Di Lucia, Pietro ; Klaus, Michael ; Bollag, Werner ; Ho, I. Cheng ; Sinigaglia, Francesco ; Panina-Bordignon, Paola. / Cutting edge : Inhibition of the retinoid X receptor (RXR) blocks T helper 2 differentiation and prevents allergic lung inflammation. In: Journal of Immunology. 2006 ; Vol. 176, No. 9. pp. 5161-5166.
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