Abstract
Among the many factors regulating Th cell differentiation, some nuclear hormone receptors are emerging as important players. The retinoid X receptor (RXR) functions as heterodimerization partner for a variety of nuclear hormone receptors. We show in this study that RXR is critical for Th2-mediated immunity. An RXR antagonist inhibited Th2 differentiation, resulting in reduced production of IL-4, IL-10, and IL-13, whereas IFN-γ production was enhanced. This effect was dependent on the presence of APCs. In addition, IL-5 production was blocked directly in Th cells. In vivo, inhibition of RXR prevented experimentally induced allergic lung inflammation. Th1-mediated inflammation was not affected. Its specific role in Th2-mediated inflammation makes RXR a promising target for the development of therapies against diseases such as allergic asthma and atopic dermatitis.
| Original language | English |
|---|---|
| Pages (from-to) | 5161-5166 |
| Number of pages | 6 |
| Journal | Journal of Immunology |
| Volume | 176 |
| Issue number | 9 |
| Publication status | Published - May 1 2006 |
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ASJC Scopus subject areas
- Immunology
Cite this
Cutting edge : Inhibition of the retinoid X receptor (RXR) blocks T helper 2 differentiation and prevents allergic lung inflammation. / Grenningloh, Roland; Gho, Andrea; Di Lucia, Pietro; Klaus, Michael; Bollag, Werner; Ho, I. Cheng; Sinigaglia, Francesco; Panina-Bordignon, Paola.
In: Journal of Immunology, Vol. 176, No. 9, 01.05.2006, p. 5161-5166.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cutting edge
T2 - Inhibition of the retinoid X receptor (RXR) blocks T helper 2 differentiation and prevents allergic lung inflammation
AU - Grenningloh, Roland
AU - Gho, Andrea
AU - Di Lucia, Pietro
AU - Klaus, Michael
AU - Bollag, Werner
AU - Ho, I. Cheng
AU - Sinigaglia, Francesco
AU - Panina-Bordignon, Paola
PY - 2006/5/1
Y1 - 2006/5/1
N2 - Among the many factors regulating Th cell differentiation, some nuclear hormone receptors are emerging as important players. The retinoid X receptor (RXR) functions as heterodimerization partner for a variety of nuclear hormone receptors. We show in this study that RXR is critical for Th2-mediated immunity. An RXR antagonist inhibited Th2 differentiation, resulting in reduced production of IL-4, IL-10, and IL-13, whereas IFN-γ production was enhanced. This effect was dependent on the presence of APCs. In addition, IL-5 production was blocked directly in Th cells. In vivo, inhibition of RXR prevented experimentally induced allergic lung inflammation. Th1-mediated inflammation was not affected. Its specific role in Th2-mediated inflammation makes RXR a promising target for the development of therapies against diseases such as allergic asthma and atopic dermatitis.
AB - Among the many factors regulating Th cell differentiation, some nuclear hormone receptors are emerging as important players. The retinoid X receptor (RXR) functions as heterodimerization partner for a variety of nuclear hormone receptors. We show in this study that RXR is critical for Th2-mediated immunity. An RXR antagonist inhibited Th2 differentiation, resulting in reduced production of IL-4, IL-10, and IL-13, whereas IFN-γ production was enhanced. This effect was dependent on the presence of APCs. In addition, IL-5 production was blocked directly in Th cells. In vivo, inhibition of RXR prevented experimentally induced allergic lung inflammation. Th1-mediated inflammation was not affected. Its specific role in Th2-mediated inflammation makes RXR a promising target for the development of therapies against diseases such as allergic asthma and atopic dermatitis.
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UR - http://www.scopus.com/inward/citedby.url?scp=33645971026&partnerID=8YFLogxK
M3 - Article
VL - 176
SP - 5161
EP - 5166
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 9
ER -