Cutting-edge issues in autoimmunity and allergy of the digestive system

Research output: Contribution to journalArticle

Abstract

Autoimmunity and allergy involving the digestive system may be considered as paradigmatic for numerous common themes of complex diseases secondary to tolerance breakdown. Among gastrointestinal autoimmune diseases, for example, we encounter diseases in which a clear environmental trigger is identified (i.e., celiac disease), serum autoantibodies are most specific (i.e., primary biliary cirrhosis), or in which the disease pathophysiology is clearly understood (i.e., autoimmune gastritis). Similarly, it is intriguing that the gastrointestinal tract and the liver circulation represent the crucial environment for the development of immune tolerance. This issue is dedicated to the discussion of recent concepts while identifying two major common issues, i.e., the need for serum biomarkers and the role of vitamin D. Other common themes characterize the etiology and effector mechanisms of these and other autoimmune diseases and are discussed in each cutting-edge overview.

Original languageEnglish
Pages (from-to)265-268
Number of pages4
JournalClinical Reviews in Allergy and Immunology
Volume42
Issue number3
DOIs
Publication statusPublished - Jun 2012

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Digestive System
Autoimmunity
Hypersensitivity
Autoimmune Diseases
Liver Circulation
Immune Tolerance
Biliary Liver Cirrhosis
Gastrointestinal Diseases
Celiac Disease
Gastritis
Serum
Vitamin D
Autoantibodies
Gastrointestinal Tract
Biomarkers

Keywords

  • Adjuvant
  • Autoantibody
  • Tolerance
  • Vitamin D

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Cutting-edge issues in autoimmunity and allergy of the digestive system. / Selmi, Carlo.

In: Clinical Reviews in Allergy and Immunology, Vol. 42, No. 3, 06.2012, p. 265-268.

Research output: Contribution to journalArticle

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