Cutting edge: Selective usage of chemokine receptors by plasmacytoid dendritic cells

G. Penna, S. Sozzani, L. Adorini

Research output: Contribution to journalArticle

Abstract

The existence of dendritic cell (DC) subsets is firmly established, but their trafficking properties are virtually unknown. In this study, we show that myeloid (M-DCs) and plasmacytoid (P-DCs) DCs isolated from human blood differ widely in the capacity to migrate to chemotactic stimuli. The pattern of chemokine receptors expressed by blood M-DCs and P-DCs, with the exception of CCR7, is similar. However, most chemokine receptors of P-DCs, in particular those specific for inflammatory chemokines and classical chemotactic agonists, are not functional in circulating cells. Following maturation induced by CD40 ligation, the receptors for inflammatory chemokines are down-regulated, and CCR7 on P-DCs becomes coupled to migration. The drastically impaired capacity of blood P-DCs to migrate in response to inflammatory chemotactic signals contrasts with the response to lymph node-homing chemokines, indicating a propensity to migrate to secondary lymphoid organs rather than to sites of inflammation.

Original languageEnglish
Pages (from-to)1862-1866
Number of pages5
JournalJournal of Immunology
Volume167
Issue number4
Publication statusPublished - Aug 15 2001

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ASJC Scopus subject areas

  • Immunology

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