Cutting edge: TGF-β1 and IL-15 induce FOXP3+ γδ regulatory T cells in the presence of antigen stimulation

Rita Casetti, Chiara Agrati, Marianne Wallace, Alessandra Sacchi, Federico Martini, Angelo Martino, Alessandra Rinaldi, Miroslav Malkovsky

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Several subsets of αβ regulatory T cells (Tregs) have been described and studied intensively, but the potential regulatory role of γδ T cells remains largely unclear. Lymphocytes expressing γδ TCR are involved in both innate and adaptive immune responses, and their major adult human peripheral blood subset (Vγ9Vδ2) displays a broad reactivity against microbial agents and tumors. In this study we report that γδ T lymphocytes with regulatory functions (Vδ2 Tregs) are induced in vitro in the presence of specific Ag stimulation and cytokines (TGF-β1 and IL-15). These cells express FOXP3 and, similarly as αβ Tregs, suppress the proliferation of anti-CD3/anti-CD28 stimulated-PBMC. Phenotypic and functional analyses of Vδ2 Tregs will very likely improve our understanding about the role of γδ T cells in the pathogenesis of autoimmune, infectious, and neoplastic diseases.

Original languageEnglish
Pages (from-to)3574-3577
Number of pages4
JournalJournal of Immunology
Issue number6
Publication statusPublished - Sep 15 2009


ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

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