CX 3CR1 deficiency alters hippocampal-dependent plasticity phenomena blunting the effects of enriched environment

Laura Maggi, Maria Scianni, Igor Branchi, Ivana D'Andrea, Clotilde Lauro, Cristina Limatola

Research output: Contribution to journalArticlepeer-review

Abstract

In recent years several evidence demonstrated that some features of hippocampal biology, like neurogenesis, synaptic transmission, learning, and memory performances are deeply modulated by social, motor, and sensorial experiences. Fractalkine/CX 3CL1 is a transmembrane chemokine abundantly expressed in the brain by neurons, where it modulates glutamatergic transmission and long-term plasticity processes regulating the intercellular communication between glia and neurons, being its specific receptor CX 3CR1 expressed by microglia. In this paper we investigated the role of CX 3CL1/CX 3CR1 signaling on experience-dependent hippocampal plasticity processes. At this aim wt and CX 3CR1 GFP/GFP mice were exposed to long-lasting-enriched environment (EE) and the effects on hippocampal functions were studied by electrophysiological recordings of long term potentiation of synaptic activity, behavioral tests of learning and memory in the Morris water maze paradigm and analysis of neurogenesis in the subgranular zone of the dentate gyrus (DG). We found that CX3CR1 deficiency increases hippocampal plasticity and spatial memory, blunting the potentiating effects of EE. In contrast, exposure to EE increased the number and migration of neural progenitors in the DG of both wt and CX 3CR1 GFP/GFP mice. These data indicate that CX 3CL1/CX3CR1-mediated signaling is crucial for a normal experience-dependent modulation of hippocampal functions.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalFrontiers in Cellular Neuroscience
Issue numberOCTOBER
DOIs
Publication statusPublished - Oct 19 2011

Keywords

  • CX CL1
  • Experiencee
  • Learning and memory
  • Long-term potentiation
  • Neurogenesis

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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