CXCL10 haplotypes and multiple sclerosis: Association and correlation with clinical course

D. Galimberti, D. Scalabrini, C. Fenoglio, C. Comi, M. De Riz, E. Venturelli, C. Lovati, C. Mariani, F. Monaco, N. Bresolin, E. Scarpini

Research output: Contribution to journalArticle

Abstract

CXCL10 (interferon-γ-inducible protein-10) levels are increased in cerebrospinal fluid of multiple sclerosis (MS) patients with symptomatic attacks of inflammatory demyelination, supporting a role for this molecule in MS pathogenesis. Two hundred and twenty-six patients with MS and 235 controls were genotyped for G → C and T → C single nucleotide polymorphisms (SNPs) in exon 4 of CXCL10 gene. Haplotypes were tested for association and correlated with clinical variables. The two SNPs studied were in complete linkage disequilibrium. None of the determined haplotypes was associated with MS. However, carriers of the GGTT haplotype (defined as wild type, according to the sequence in National Centre for Biotechnology Information (NCBI) database) had a significantly lower progression index than non-carriers (P = 0.016). Furthermore, amongst patients who had an initial relapsing remitting (RR) course of the disease, the time between onset and second episode was significantly longer in GGTT carriers (P = 0.021). Considering secondary progressive (SP)-MS patients, the time between the initial RR form and the subsequent worsening to SP was longer in this group (P = 0.08). Therefore, the GGTT haplotype of the CXCL10 gene is not a susceptibility factor for the development of MS, but is probably to influence the course of MS, possibly contributing to slow down the progression of the disease.

Original languageEnglish
Pages (from-to)162-167
Number of pages6
JournalEuropean Journal of Neurology
Volume14
Issue number2
DOIs
Publication statusPublished - Feb 2007

Keywords

  • Clinical course
  • CXCL10
  • Haplotypes
  • Interferon-γ-inducible protein-10 polymorphisms
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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