CXCL13 (BCA-1) is produced by follicular lymphoma cells: Role in the accumulation of malignant B cells

Hervé Husson, Arnold S. Freedman, Angelo A. Cardoso, Joachim Schultze, Olivier Munoz, Giuliana Strola, Jeffery Kutok, Elizabeth G. Carideo, Rosalie De Beaumont, Federico Caligaris-Cappio, Paolo Ghia

Research output: Contribution to journalArticle

Abstract

Follicular lymphomas (FLs) localize in lymphoid tissues and recapitulate the structure of normal secondary follicles. The chemokine/chemokine receptor pair CXCL13/CXCR5 is required for the architectural organization of B cells within lymphoid follicles. In this study, we showed that CXCL13 was secreted by FL cells. FL cells expressed CXCR5 and migrated in response to CXCL13. Furthermore, we observed a synergistic effect between CXCL13 and CXCL12 (SDF-1), a chemokine produced by stromal cells in lymphoid tissues. The production of CXCL13 by FL cells and CXCL12 by stromal cells probably directs and participates in the accumulation of FL cells within specific anatomic sites.

Original languageEnglish
Pages (from-to)492-495
Number of pages4
JournalBritish Journal of Haematology
Volume119
Issue number2
DOIs
Publication statusPublished - 2002

Keywords

  • CXCL12
  • CXCL13
  • Follicular lymphomas

ASJC Scopus subject areas

  • Hematology

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    Husson, H., Freedman, A. S., Cardoso, A. A., Schultze, J., Munoz, O., Strola, G., Kutok, J., Carideo, E. G., De Beaumont, R., Caligaris-Cappio, F., & Ghia, P. (2002). CXCL13 (BCA-1) is produced by follicular lymphoma cells: Role in the accumulation of malignant B cells. British Journal of Haematology, 119(2), 492-495. https://doi.org/10.1046/j.1365-2141.2002.03832.x